Brasil
| Artigo
Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19
dc.creator | Hu, Xiaowen | |
dc.creator | Xing, Yuhan | |
dc.creator | Jia, Jing | |
dc.creator | Ni, Wei | |
dc.creator | Liang, Jiwei | |
dc.creator | Zhao, Dan | |
dc.creator | Song, Xin | |
dc.creator | Gao, Ruqin | |
dc.creator | Jiang, Fachun | |
dc.date | 2020-08-21T13:11:11Z | |
dc.date | 2020-08-21T13:11:11Z | |
dc.date | 2020-08 | |
dc.date.accessioned | 2023-09-28T20:08:39Z | |
dc.date.available | 2023-09-28T20:08:39Z | |
dc.identifier | HU, X. et al. Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19. Science of The Total Environment, [S.l.], v. 728, Aug. 2020. | |
dc.identifier | https://www.sciencedirect.com/science/article/pii/S0048969720323299 | |
dc.identifier | http://repositorio.ufla.br/jspui/handle/1/42517 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9045510 | |
dc.description | Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR: 0–2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR: 10–18) days, and 7 (IQR: 6–10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR: 0.378; 95% confidence interval, CI: 0.205–0.698) and chest tightness (HR: 0.290; 95%CI: 0.091–0.919) were factors independently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio: 7.553; 95%CI: 1.011–28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies. | |
dc.language | en_US | |
dc.publisher | Elsevier | |
dc.rights | restrictAccess | |
dc.source | Science of The Total Environment | |
dc.subject | COVID-19 | |
dc.subject | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | |
dc.subject | Negative conversion | |
dc.subject | Hazard ratio | |
dc.title | Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19 | |
dc.type | Artigo |