The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): a role for iron homeostasis?

dc.creatorQuiros Roldan, Eugenia
dc.creatorBiasiotto, Giorgio
dc.creatorMagro, Paola
dc.creatorZanella, Isabella
dc.date2020-05-27T16:11:08Z
dc.date2020-05-27T16:11:08Z
dc.date2020-08
dc.date.accessioned2023-09-28T20:05:26Z
dc.date.available2023-09-28T20:05:26Z
dc.identifierQUIROS ROLDAN, E. et al. The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): a role for iron homeostasis? Pharmacological Research, [S.l.], v. 158, Aug. 2020.
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1043661820312123
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/41254
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9044200
dc.descriptionThe anti-malarial drugs chloroquine (CQ) and primarily the less toxic hydroxychloroquine (HCQ) are currently used to treat autoimmune diseases for their immunomodulatory and anti-thrombotic properties. They have also been proposed for the treatment of several viral infections, due to their anti-viral effects in cell cultures and animal models, and, currently, for the treatment of coronavirus disease 2019 (COVID-19), the pandemic severe acute respiratory syndrome caused by coronavirus 2 (Sars-Cov-2) infection that is spreading all over the world. Although in some recent studies a clinical improvement in COVID-19 patients has been observed, the clinical efficacy of CQ and HCQ in COVID-19 has yet to be proven with randomized controlled studies, many of which are currently ongoing, also considering pharmacokinetics, optimal dosing regimen, therapeutic level and duration of treatment and taking into account patients with different severity degrees of disease. Here we review what is currently known on the mechanisms of action of CQ and HCQ as anti-viral, anti-inflammatory and anti-thrombotic drugs and discuss the up-to-date experimental evidence on the potential mechanisms of action of CQ/HCQ in Sars-Cov2 infection and the current clinical knowledge on their efficacy in the treatment of COVID-19 patients. Given the role of iron in several human viral infections, we also propose a different insight into a number of CQ and HCQ pharmacological effects, suggesting a potential involvement of iron homeostasis in Sars-Cov-2 infection and COVID-19 clinical course.
dc.languageen_US
dc.publisherElsevier
dc.rightsrestrictAccess
dc.sourcePharmacological Research
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
dc.subjectCOVID-19
dc.subjectChloroquine/hydroxychloroquine
dc.subjectIron
dc.subjectInflammation
dc.subjectThrombosis
dc.titleThe possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): a role for iron homeostasis?
dc.typeArtigo


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