Use of diffusion‐ordered NMR spectroscopy and HPLC-UV-SPE-NMR to identify undeclared synthetic drugs in medicines illegally sold as phytotherapies

dc.creatorSilva, Lorena M. A.
dc.creatorA. Filho, Elenilson G.
dc.creatorThomasi, Sérgio S.
dc.creatorSilva, Bianca F.
dc.creatorFerreira, Antonio G.
dc.creatorVenâncio, Tiago
dc.date2020-05-18T03:51:12Z
dc.date2020-05-18T03:51:12Z
dc.date2013-09
dc.date.accessioned2023-09-28T20:04:28Z
dc.date.available2023-09-28T20:04:28Z
dc.identifierSILVA, L. M. A. et al. Use of diffusion‐ordered NMR spectroscopy and HPLC-UV-SPE-NMR to identify undeclared synthetic drugs in medicines illegally sold as phytotherapies. Magnetic Resonance in Chemistry, [S.l.], v. 51, n. 9, p. 541-548, Sept. 2013. DOI: 10.1002/mrc.3984.
dc.identifierhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mrc.3984
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/40984
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9043790
dc.descriptionThe informal (and/or illegal) e‐commerce of pharmaceutical formulations causes problems that governmental health agencies find hard to control, one of which concerns formulas sold as natural products. The purpose of this work was to explore the advantages and limitations of DOSY and HPLC–UV–SPE–NMR. These techniques were used to identify the components of a formula illegally marketed in Brazil as an herbal medicine possessing anti‐inflammatory and analgesic properties. DOSY was able to detect the major components present at higher concentrations. Complete characterization was achieved using HPLC–UV–SPE–NMR, and 1D and 2D NMR analyses enabled the identification of known synthetic drugs. These were ranitidine and a mixture of orphenadrine citrate, piroxicam, and dexamethasone, which are co‐formulated in a remedy called Rheumazim that is used to relieve severe pain, but it is prohibited in Brazil because of a lack of sufficient pharmacokinetic and pharmacodynamic information.
dc.languageen_US
dc.publisherWiley
dc.rightsrestrictAccess
dc.sourceMagnetic Resonance in Chemistry
dc.subjectDOSY
dc.subjectHPLC-UV-SPE-NMR
dc.subjectDrug adulteration
dc.subjectUnknown formulas
dc.subjectIllegal e‐commerce
dc.subjectDiffusion-ordered spectroscopy (DOSY)
dc.subjectHigh performance liquid chromatography coupled to on-line solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-UV-SPE-NMR)
dc.titleUse of diffusion‐ordered NMR spectroscopy and HPLC-UV-SPE-NMR to identify undeclared synthetic drugs in medicines illegally sold as phytotherapies
dc.typeArtigo


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