Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock

dc.creatorNoritomi, Danilo Teixeira
dc.creatorPereira, Adriano José
dc.creatorBugano, Diogo Diniz Gomes
dc.creatorRehder, Paulo Sergio
dc.creatorSilva, Eliézer
dc.date2017-02-17T16:04:47Z
dc.date2017-02-17T16:04:47Z
dc.date2011-07-13
dc.date.accessioned2023-09-28T20:01:09Z
dc.date.available2023-09-28T20:01:09Z
dc.identifierNORITOMI, D. T. et al. Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock. Clinics, São Paulo, v. 66, n. 11, p. 1969-1974, 2011.
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/12311
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9042488
dc.descriptionOBJECTIVE: Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions on the hemodynamics and acid-base balance. METHODS: Controlled hemorrhagic shock (40% of the total blood volume was removed) was induced in 18 animals, which were then treated with normal saline (0.9% NaCl), Lactated Ringer's Solution or Plasma-Lyte pH 7.4, in a blinded fashion (n = 6 for each group). Using a predefined protocol, the animals received three times the volume of blood removed. RESULTS: The three different crystalloid infusions were equally capable of reversing the hemorrhage-induced low cardiac output and anuria. The Lactated Ringer's Solution and Plasma-Lyte pH 7.4 infusions resulted in an increased standard base excess and a decreased serum chloride level, whereas treatment with normal saline resulted in a decreased standard base excess and an increased serum chloride level. The Plasma-Lyte pH 7.4 infusions did not change the level of the unmeasured anions. CONCLUSION: Although the three tested crystalloid solutions were equally able to attenuate the hemodynamic and tissue perfusion disturbances, only the normal saline induced hyperchloremia and metabolic acidosis.
dc.formatapplication/pdf
dc.languageen_US
dc.publisherUniversidade de São Paulo
dc.rightsacesso aberto
dc.sourceClinics
dc.subjectHemorrhagic shock
dc.subjectIsotonic solutions
dc.subjectAcid-base equilibrium
dc.subjectSwine as laboratory animals
dc.subjectChoque hemorrágico
dc.subjectSoluções isotônicas
dc.subjectEquilíbrio ácido-base
dc.subjectSuíno como animal de laboratório
dc.titleImpact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock
dc.typeArtigo


Este ítem pertenece a la siguiente institución