dc.creatorYazdanpanah, Fereshteh
dc.creatorHamblin, Michael R.
dc.creatorRezaei, Nima
dc.date2020-09-14T19:40:06Z
dc.date2020-09-14T19:40:06Z
dc.date2020-09
dc.date.accessioned2023-09-28T20:00:15Z
dc.date.available2023-09-28T20:00:15Z
dc.identifierYAZDANPANAH, F.; HAMBLIN, M. R.; REZAEI, N. The immune system and COVID-19: friend or foe? Life Sciences, [S.l.], v. 256, Sept. 2020.
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0024320520306500
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/43058
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9042104
dc.descriptionAim Coronavirus disease 2019 (COVID-19) is a novel highly contagious infection caused by SARS-CoV-2, which has been became a global public health challenge. The pathogenesis of this virus is not yet clearly understood, but there is evidence of a hyper-inflammatory immune response in critically ill patients, which leads to acute respiratory distress syndrome (ARDS) and multi-organ failure. Material and methods A literature review was performed to identify relevant articles on COVID-19 published up to April 30, 2020. The search resulted in 361 total articles. After reviewing the titles and abstracts for inclusion, some irrelevant papers were excluded. Additional relevant articles were identified from a review of citations referenced. Key findings SARS-CoV-2, directly and indirectly, affects the immune system and avoids being eliminated in early stages. On the other hand, the secretion of inflammatory cytokines creates critical conditions that lead to multi-organ failure. Significance The immune system which is affected by the virus tries to respond via a cytokine storm and hyperinflammation, which itself leads to further multi-organ damage and even death.
dc.languageen_US
dc.publisherElsevier
dc.rightsrestrictAccess
dc.sourceLife Sciences
dc.subjectCOVID-19
dc.subjectImmune system
dc.subjectAcute Respiratory Distress Syndrome (ARDS)
dc.subjectHyperinflammation
dc.subjectCytokine storm
dc.titleThe immune system and COVID-19: friend or foe?
dc.typeArtigo


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