Eucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity

dc.creatorEsposito, Mariana Araújo
dc.creatorCesar, Pedro Henrique Souza
dc.creatorBrandão, Rafaela Magalhães
dc.creatorAbreu, Tatiane Silva de
dc.creatorMarcussi, Silvana
dc.date2022-01-07T15:32:34Z
dc.date2022-01-07T15:32:34Z
dc.date2021
dc.date.accessioned2023-09-28T20:00:01Z
dc.date.available2023-09-28T20:00:01Z
dc.identifierESPOSITO, M. A. et al. Eucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity. Brazilian Archives of Biology and Technology, [S.l.], v. 64, p. 1-10, 2021. DOI: 10.1590/1678-4324-2021210109.
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/48806
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9042017
dc.descriptionThe genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole. Both essential oils prevented thrombus dissolution and reduced clotting, hemolysis, and genotoxicity induced by snake venoms. 50% (EM) and 73% (EG) were the greatest inhibitions obtained in the thrombolytic assay - thrombolysis induced by B. moojeni venom. Increases in clotting time were also observed, with values considered significant between 10-27 seconds. Lysis values 50% lower than the negative control were observed in both EOs. The EOs also protected fibrinogenolysis induced by snake venom. EM EO was more effective in reducing venom-induced DNA fragmentation in the comet assay, with arbitrary unit values 66.15% lower than the positive control. These oils present wide application potential considering the pharmacological properties observed in this study.
dc.formatapplication/pdf
dc.languageen_US
dc.publisherWiley
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsacesso aberto
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceBrazilian Archives of Biology and Technology
dc.subject1,8-cineole
dc.subjectSnake venom proteases
dc.subjectComet assay
dc.subjectChemical characterization
dc.subjectEnzyme inhibitors
dc.subjectHemostasis
dc.titleEucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity
dc.typeArtigo


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