Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy

dc.creatorYasuda, Clarissa Lin
dc.creatorValise, Clarissa
dc.creatorSaúde, André Vital
dc.creatorPereira, Amanda Régio
dc.creatorPereira, Fabrício Ramos
dc.creatorCosta, André Luiz Ferreira
dc.creatorMorita, Márcia Elisabete
dc.creatorBetting, Luiz Eduardo
dc.creatorCastellano, Gabriela
dc.creatorGuerreiro, Carlos Alberto Mantovani
dc.creatorTedeschi, Helder
dc.creatorOliveira, Evandro de Evandro de
dc.creatorCendes, Fernando
dc.date2017-02-16T12:27:08Z
dc.date2017-02-16T12:27:08Z
dc.date2010-01-01
dc.date.accessioned2023-09-28T19:57:51Z
dc.date.available2023-09-28T19:57:51Z
dc.identifierYASUDA, C. L. et al. Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy. NeuroImage, Orlando, v. 49, n. 1, p. 71-79, Jan. 2010.
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S105381190900891X
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/12283
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9041204
dc.descriptionBackground: The reasons for surgical failure in 30% of patients with unilateral mesial temporal lobe epilepsy (MTLE) are still unclear. We investigated if different outcomes could be associated to different patterns of subtle gray matter atrophy (GMA) and white matter atrophy (WMA), and searched for postoperative magnetic resonance imaging (MRI) changes. Methods: We studied 69 controls and 67 operated patients with refractory unilateral MTLE. Patients were grouped as seizure-free (SF) group (34 patients Engel's IA), worthwhile improvement group (23 patients, Engel's IB–IIA) and failure group (10 patients Engel's IIB–IV). We created a voxel-based morphometry/MATLAB code to mask the surgical lacuna, and performed t-test and paired t-test to evaluate preoperative and postoperative MRI scans. Results: Failure group showed a widespread pattern of preoperative GMA. On SF and improvement groups we identified a more restricted pattern of GMA. The three groups presented a widespread, bilateral pattern of WMA. In contrast, postoperative analyses showed bilateral hemispheric recovery (a relative increase of WM concentration) on SF and improvement groups, but few changes on failure group. We also identified areas with relative postoperative increase of GM on both SF and improvement groups, more widespread on SF group. Conclusion: Areas of subtle GMA may be related to poorer surgical outcome. In addition, we demonstrated a postoperative relative increase of WM and GM concentration associated with seizure control. These changes may represent neuroplasticity related to improvement of brain function after seizure control. Further studies with a multimodal approach may help to predict surgical outcome and improve selection of patients for surgical treatment of MTLE.
dc.languageen_US
dc.publisherElsevier
dc.rightsrestrictAccess
dc.sourceNeuroImage
dc.subjectEpilepsy – Surgery
dc.subjectMagnetic Resonance Imaging (MRI)
dc.subjectWhite matter atrophy (WMA)
dc.subjectGray matter atrophy (GMA)
dc.subjectEpilepsia – Cirurgia
dc.subjectImagem por Ressonância Magnética
dc.subjectSubstância branca – Atrofia
dc.subjectSubstância cinzenta – Atrofia
dc.titleDynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy
dc.typeArtigo


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