Pretreatment With L‐citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model

dc.creatorAntunes, Maísa Mota
dc.creatorLeocádio, Paola Caroline Lacerda
dc.creatorTeixeira, Lílian Gonçalves
dc.creatorLeonel, Alda Jusceline
dc.creatorCara, Denise Carmona
dc.creatorMenezes, Gustavo Batista
dc.creatorGeneroso, Simone de Vasconcelos
dc.creatorCardoso, Valbert Nascimento
dc.creatorAlvarez‐Leite, Jacqueline Isaura
dc.creatorCorreia, Maria Isabel Toulson Davisson
dc.date2018-11-09T16:00:44Z
dc.date2018-11-09T16:00:44Z
dc.date2016-02
dc.date.accessioned2023-09-28T19:56:01Z
dc.date.available2023-09-28T19:56:01Z
dc.identifierANTUNES, M. M. et al. Pretreatment With L‐citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model. Journal of Parenteral and Enteral Nutrition, Silver Spring, v. 40, n. 2, p. 279-286, Feb. 2016.
dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1177/0148607114567508
dc.identifierhttp://repositorio.ufla.br/jspui/handle/1/31710
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9040488
dc.descriptionBackground: Mucositis is a common complication in patients undergoing radiotherapy and chemotherapy. It is associated with pain, poor quality of life, and malnutrition, leading to an increased number of hospital admissions and prolonged hospitalization. The use of immunonutrients may be an alternative treatment option, which may help to improve patient outcome. Objective: Here we assessed the impact of L‐citrulline (CIT) on a murine model of 5‐fluorouracil (5FU)–induced mucositis. Methods: Swiss male mice were randomized into 4 groups: control, CIT, 5FU, and 5FU+CIT. Mice were fed with commercial chow and supplemented with an oral solution of alanine (control and 5FU groups) or CIT (CIT and 5FU+CIT groups). On the seventh day, mice received intraperitoneal phosphate‐buffered saline or 5FU (200 mg/kg, single dose) to induce mucositis. On the 10th day, mice were euthanized, and the blood and small intestines were harvested. Body weight, morphology, histopathology score (hematoxylin and eosin) of the small intestine (from 0–12), myeloperoxidase activity, oxidative stress level, and intestinal permeability were assessed. Results: We observed significant weight loss after the administration of 5FU in both treated and control animals. CIT administration contributed to a partial recovery of the mucosal architecture as well as an intermediate reduction of the histopathologic score, and functional intestinal permeability was partially rescued. Conclusions: CIT administration attenuated 5FU‐mediated damage to the mucosal architecture of the small intestine, decreasing the size of the injured areas and promoting decreased intestinal permeability.
dc.languageen_US
dc.publisherAmerican Society for Parenteral and Enteral Nutrition
dc.rightsrestrictAccess
dc.sourceJournal of Parenteral and Enteral Nutrition
dc.subjectL‐citrulline
dc.subjectMucositis
dc.subjectIntestinal permeability
dc.subjectL-citrulina
dc.subjectMucosite
dc.subjectPermeabilidade intestinal
dc.titlePretreatment With L‐citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model
dc.typeArtigo


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