| dc.contributor | Bruck, Isac, 1935- | |
| dc.contributor | Antoniuk, Sérgio Antônio, 1955- | |
| dc.contributor | Universidade Federal do Paraná | |
| dc.creator | Silva, Cristina Andrade da | |
| dc.date | 2022-11-16T20:42:39Z | |
| dc.date | 2022-11-16T20:42:39Z | |
| dc.date | 1995 | |
| dc.date.accessioned | 2023-09-28T17:39:50Z | |
| dc.date.available | 2023-09-28T17:39:50Z | |
| dc.identifier | https://hdl.handle.net/1884/31982 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9026213 | |
| dc.description | Orientador: Isac Bruck | |
| dc.description | Co-orientador: Sergio Antonio Antoniuk | |
| dc.description | Dissertação (mestrado) - Universidade Federal do Parana | |
| dc.description | Resumo: Estudou-se prospectivamente 175 pacientes pediatricos com crises parciais ou generalizadas tonicas, clonicas ou tonico-clonicas nao provocadas e de inicio recente por um periodo medio de 27 meses. Analisou-se os fatores possivelmente relacionados a um aumento no indice de recorrencia da primeira crise e os efeitos colaterais comportamentais das drogas antiepilepticas utilizadas. O indice geral de recorrencia foi de 44%. Cerca de 80% dos individuos que recorreram, o fizeram ate o 6o mes apos o primeiro episodio. Os pacientes com crises sintomaticas remotas sofreram recorrencia em 62,50% dos casos, enquanto que os pacientes com crises criptogenicas tiveram indices de recorrencia de 45,36% (p=0,0927). Sexo, idade, condicoes socio-economicas, tipo de crise, historia familiar de crises e estado de mal epileptico nao foram relacionados a um aumento nos indices de recorrencia tanto nos individuos com crises criptogenicas como nos individuos com crises sintomaticas remotas. No grupo criptogenico somente o eletroencefalograma foi fator de previsao de recorrencia, enquanto que no grupo de pacientes com crises sintomaticas remotas a existencia de mais de uma crise em 24 horas esteve relacionada a um maior indice de recorrencia. O tratamento com drogas antiepilepticas (DAE) foi utilizado em 30,89% dos pacientes apos a primeira crise. Observou-se uma reducao no risco de recorrencia de 65,88% para 5,26% quando utilizou-se DAE imediatamente apos a primeira crise. Efeitos comportamentais foram observados nos pacientes que utilizaram o fenobarbital. | |
| dc.description | Abstract: 175 pediatric patients that recently had a non-provoked tonic, clonic or tonic-clonic seizures, both partial and generalized were prospectively studied by a mean period of 27 months. Forecast factors related to an increase in the rate of recurrence of the first seizure as well as possible collateral behavioral effects of the antiepileptic drugs prescribed were also analysed. The overall recurrence rate was 44%. In approximately 80% of the patients suffering recurrences these occured within 6 months from the first episode. Patients with remote symptomatic seizures experienced recurrences in 62.50% of the cases, while patients with cryptogenic seizures experienced recurrence rate of 45.36% (p=0.0927). Sex, age, socio-economic conditions, types of seizures, occurrence of seizures in the family and status epilepticus were not related to an increase in recurrence rate, either in individuals with cryptogenic seizures or remote symptomatic seizures. As far as the link between recurrence rate and type of seizures the EEG was the only factor that forecast recurrences of seizures in the cryptogenic group, while in the remote symptomatic patients only the occurence of more than one seizures in 24 hours was related to a higher incidence of recurrences. Treatment was started with antiepileptic drugs (AED) in 30.39% of the patients following the first seizure. A decrease in recurrence rate from 65.88% to 5.26% was observed in patients who were given AED immediately after the first seizure. Behavioral changes were observed in patients on the use of phenobarbital. | |
| dc.format | 195 f. : tabs. ; 30 cm. | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | Português | |
| dc.relation | Disponívl em formato digital. | |
| dc.subject | Crianças epiléticas | |
| dc.title | Estudo prospectivo sobre o prognostico de crises epilepticas recentes não provocadas ocorridas em crianças atendidas em um hospital universitario | |
| dc.type | Dissertação | |
