Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

dc.creatorCARVALHAES, Fernanda Andreza de Pinho Lott
dc.creatorCARDOSO, Greice de Lemos
dc.creatorVALLINOTO, Antonio Carlos Rosário
dc.creatorMACHADO, Luiz Fernando Almeida
dc.creatorISHAK, Marluísa de Oliveira Guimarães
dc.creatorISHAK, Ricardo
dc.creatorGUERREIRO, João Farias
dc.date2013-03-26T15:19:03Z
dc.date2013-03-26T15:19:03Z
dc.date2005-12
dc.date.accessioned2023-09-28T15:55:20Z
dc.date.available2023-09-28T15:55:20Z
dc.identifierCARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <http://www.scielo.br/pdf/gmb/v28n4/a04v28n4.pdf>. Acesso em: 25 mar. 2013. <http://dx.doi.org/10.1590/S1415-47572005000500004>.
dc.identifier1678-4685
dc.identifier1415-4757
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/3595
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9023639
dc.descriptionThe distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.
dc.formatapplication/pdf
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectPolimorfismo genético
dc.subjectReceptor CCR2
dc.subjectReceptor CCR5
dc.subjectReceptor SDF1
dc.subjectHIV-1
dc.subjectSíndrome de Imunodeficiência Adquirida
dc.subjectFrequência do gene
dc.subjectBelém - PA
dc.subjectPará - Estado
dc.subjectAmazônia brasileira
dc.titleFrequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
dc.typeArtigo de Periódico


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