Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab

Tomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabe

dc.creatorALMEIDA, Izabela Negrão Frota de
dc.creatorALMEIDA, Luciana Negrão Frota de
dc.creatorSOBRINHO, Edmundo Frota de Almeida
dc.creatorGOMES, Bruno Duarte
dc.creatorSOUZA, Givago da Silva
dc.creatorROSA, Alexandre Antonio Marques
dc.creatorSILVEIRA, Luiz Carlos Lima
dc.date2019-04-05T19:05:03Z
dc.date2019-04-05T19:05:03Z
dc.date2015-06-02
dc.date.accessioned2023-09-28T15:49:04Z
dc.date.available2023-09-28T15:49:04Z
dc.identifierALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.
dc.identifier0004-2749
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/10874
dc.identifierhttp://dx.doi.org/10.5935/0004-2749.20150027
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9021742
dc.descriptionTo evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.
dc.descriptionGOMES, Bruno Duarte. Universidade Federal do Pará, Instituto de Ciências Biológicas (ICB)
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade Federal do Pará
dc.publisherBrasil
dc.publisherUFPA
dc.relationArquivos Brasileiros de Oftalmologia
dc.rightsAcesso Aberto
dc.sourcehttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000200010&lng=pt&nrm=iso
dc.subjectMacular degeneration/drug therapy
dc.subjectAntibodies
dc.subjectTomography optical coherence
dc.subjectElectroretinography
dc.subjectIntravitreal injections
dc.titleOptical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
dc.titleTomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabe
dc.typeArtigo de Periódico


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