Ultrastructural evaluation of the radioprotective effect of sodium selenite on submandibular glands in rats

dc.creatorPONTUAL, Maria Luiza dos Anjos
dc.creatorTUJI, Fabrício Mesquita
dc.creatorBARROS, Silvana Pereira
dc.creatorBÓSCOLO, Frab Norberto
dc.creatorNOVAES, Pedro Duarte
dc.creatorALMEIDA, Solange Maria de
dc.date2015-10-20T16:15:15Z
dc.date2015-10-20T16:15:15Z
dc.date2007-06
dc.date.accessioned2023-09-28T15:45:13Z
dc.date.available2023-09-28T15:45:13Z
dc.identifierPONTUAL, Maria Luiza dos Anjos et al. Ultrastructural evaluation of the radioprotective effect of sodium selenite on submandibular glands in rats. Journal of Applied Oral Science, Bauru, v. 15, n. 3, p. 162-168, jun. 2007. Disponível em: <http://www.scielo.br/pdf/jaos/v15n3/a03v15n3.pdf>. Acesso em: 20 out. 2015. <http://dx.doi.org/10.1590/S1678-77572007000300003>.
dc.identifier1678-7765
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/6965
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9020548
dc.descriptionThe aim of this study was to evaluate the radioprotector effect of sodium selenite on the ultrastructure of submandibular glands in rats. Fifty-seven male albino Wistar rats were randomized to 4 groups: control, irradiated, sodium selenite and irradiated/sodium selenite. The animals in the sodium selenite and irradiated/sodium selenite groups received intraperitoneal injections of sodium selenite (0.5 mg/kg body weight) 24 h before irradiation. The animals belonging to the irradiated and irradiated/sodium selenite groups were submitted to 15 Gy of gamma radiation in the head and neck region. The submandibular glands were removed at 4, 8, 12, 24, 48 and 72 h after irradiation. The ionizing radiation induced damage to the secretory cells, especially the serous cells, right from the first period. Vacuolization, lysis of cytoplasmic inclusions and nuclear alterations occurred. The sodium selenite group also presented cellular alterations in the study periods, but with less damage compared to that caused by radiation. There was greater similarity between the irradiated/sodium selenite group and the control group than with the other groups treated in all study periods. Despite the alterations observed in the sodium selenite group, sodium selenite presented a radioprotective action on the secretory cells of submandibular glands.
dc.formatapplication/pdf
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectGlândula submandibular
dc.subjectSelenito de sódio
dc.subjectSelênio
dc.subjectRadioterapia
dc.subjectRadiação ionizante
dc.subjectRato como animal de laboratório
dc.titleUltrastructural evaluation of the radioprotective effect of sodium selenite on submandibular glands in rats
dc.typeArtigo de Periódico


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