JC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region

dc.creatorMELO, Fernando de Assis Ferreira
dc.creatorBEZERRA, Ana Caroline Fonseca
dc.creatorSANTANA, Bárbara Brasil
dc.creatorISHAK, Marluísa de Oliveira Guimarães
dc.creatorISHAK, Ricardo
dc.creatorVALLINOTO, Izaura Maria Vieira Cayres
dc.creatorVALLINOTO, Antonio Carlos Rosário
dc.date2014-09-15T12:51:43Z
dc.date2014-09-15T12:51:43Z
dc.date2013-04
dc.date.accessioned2023-09-28T15:29:45Z
dc.date.available2023-09-28T15:29:45Z
dc.identifierMELO, Fernando Assis Ferreira et al. JC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 2, p. 145-149, abr. 2013. Disponível em: <http://www.scielo.br/pdf/mioc/v108n2/0074-0276-mioc-108-02-0145.pdf>. Acesso em: 18 jun. 2014. http://dx.doi.org/10.1590/0074-0276108022013003.
dc.identifier0074-0276
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/5712
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9015490
dc.descriptionThis study evaluated the relative occurrences of BK virus (BKV) and JC virus (JCV) infections in patients with chronic kidney disease (CKD). Urine samples were analysed from CKD patients and from 99 patients without CKD as a control. A total of 100 urine samples were analysed from the experimental (CKD patients) group and 99 from the control group. Following DNA extraction, polymerase chain reaction (PCR) was used to amplify a 173 bp region of the gene encoding the T antigen of the BKV and JCV. JCV and BKV infections were differentiated based on the enzymatic digestion of the amplified products using BamHI endonuclease. The results indicated that none of the patients in either group was infected with the BKV, whereas 11.1% (11/99) of the control group subjects and 4% (4/100) of the kidney patients were infected with the JCV. High levels of urea in the excreted urine, low urinary cellularity, reduced bladder washout and a delay in analysing the samples may have contributed to the low prevalence of infection. The results indicate that there is a need to increase the sensitivity of assays used to detect viruses in patients with CDK, especially given that polyomavirus infections, especially BKV, can lead to a loss of kidney function following transplantation.
dc.formatapplication/pdf
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectInsuficiência renal crônica
dc.subjectInfecções por polyomavirus
dc.subjectTransplante de rim
dc.subjectVírus BK
dc.subjectVírus JC
dc.subjectAmazônia brasileira
dc.titleJC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region
dc.typeArtigo de Periódico


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