| dc.creator | LIMA, Magaly do Bom Parto Lopes Vieira | |
| dc.creator | OLIVEIRA FILHO, Aldemir Branco de | |
| dc.creator | CAMPOS, Júlia Furtado | |
| dc.creator | MELO, Fárida Coeli de Barros Correia | |
| dc.creator | NEVES, Washington Batista das | |
| dc.creator | MELO, Raul Antônio Morais | |
| dc.creator | LEMOS, José Alexandre Rodrigues de | |
| dc.date | 2015-09-10T16:01:11Z | |
| dc.date | 2015-09-10T16:01:11Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2023-09-28T15:24:46Z | |
| dc.date.available | 2023-09-28T15:24:46Z | |
| dc.identifier | LIMA, Magaly do Bom Parto Lopes Vieira et al. Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population. Genetics and Molecular Biology, São Paulo, v. 32, n. 2, p. 264-267, 2009. Disponível em: <http://www.scielo.br/pdf/gmb/v32n2/a10v32n2.pdf>. Acesso em: 8 set. 2015. <http://dx.doi.org/10.1590/S1415-47572009000200010>. | |
| dc.identifier | 1678-4685 | |
| dc.identifier | http://repositorio.ufpa.br/jspui/handle/2011/6876 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9014116 | |
| dc.description | Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.rights | Acesso Aberto | |
| dc.subject | Trombose venosa | |
| dc.subject | Fator V Leiden | |
| dc.subject | Sistema do grupo sanguíneo ABO | |
| dc.subject | Pernambuco - Estado | |
| dc.title | Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population | |
| dc.type | Artigo de Periódico | |
