Methylmercury inhibits prolactin release in a cell line of pituitary origin

dc.creatorMAUÉS, Luis Antônio Loureiro
dc.creatorMACCHI, Barbarella de Matos
dc.creatorCRESPO LÓPEZ, Maria Elena
dc.creatorNASCIUTTI, Luís Eurico
dc.creatorDINIZ, Domingos Luiz Wanderley Picanço
dc.date2017-05-17T16:37:47Z
dc.date2017-05-17T16:37:47Z
dc.date2015-08
dc.date.accessioned2023-09-28T15:20:20Z
dc.date.available2023-09-28T15:20:20Z
dc.identifierMAUES, Luís Antônio Loureiro et al. Methylmercury inhibits prolactin release in a cell line of pituitary origin. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 48, n. 8, p. 691-696, ago. 2015. Disponível em: <http://repositorio.ufpa.br/jspui/handle/2011/8442>. Acesso em:.
dc.identifier1414-431X
dc.identifierhttp://repositorio.ufpa.br/jspui/handle/2011/8442
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20154165
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9012471
dc.descriptionHeavy metals, such as methylmercury, are key environmental pollutants that easily reach human beings by bioaccumulation through the food chain. Several reports have demonstrated that endocrine organs, and especially the pituitary gland, are potential targets for mercury accumulation; however, the effects on the regulation of hormonal release are unclear. It has been suggested that serum prolactin could represent a biomarker of heavy metal exposure. The aim of this study was to evaluate the effect of methylmercury on prolactin release and the role of the nitrergic system using prolactin secretory cells (the mammosomatotroph cell line, GH3B6). Exposure to methylmercury (0-100 μM) was cytotoxic in a time- and concentration-dependent manner, with an LC50 higher than described for cells of neuronal origin, suggesting GH3B6 cells have a relative resistance. Methylmercury (at exposures as low as 1 μM for 2 h) also decreased prolactin release. Interestingly, inhibition of nitric oxide synthase by N-nitro-L-arginine completely prevented the decrease in prolactin release without acute neurotoxic effects of methylmercury. These data indicate that the decrease in prolactin production occurs via activation of the nitrergic system and is an early effect of methylmercury in cells of pituitary origin.
dc.descriptionMAUÉS, L. A. L. Dr. Docente da Universidade Federal do Pará, Campus Universitário de Altamira
dc.descriptionMACCHI, B. de M. Dr. Docente da Universidade Federal do Pará, Instituto de Ciências Biológicas
dc.descriptionCRESPO LÓPEZ, M. E. Dr. Docente da Universidade Federal do Pará, Insituto de Ciências Biológicas
dc.formatapplication/pdf
dc.languagepor
dc.publisherUniversidade Federal do Pará
dc.publisherBrasil
dc.publisherUFPA
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.sourcehttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800691&lng=pt&nrm=iso
dc.subjectMetilmercúrio
dc.subjectProlactina
dc.subjectMetais pesados
dc.subjectCélulas secretoras
dc.subjectPituitária
dc.subjectMercúrio
dc.titleMethylmercury inhibits prolactin release in a cell line of pituitary origin
dc.typeArtigo de Periódico


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