Bioinspired antimicrobial PLA with nanocones on the surface for rapid deactivation of Omicron SARS-CoV???2

dc.creatorSILVA, DANIEL J. da
dc.creatorDURAN, ADRIANA
dc.creatorCABRAL, ALINE D.
dc.creatorFONSECA, FERNANDO L.A.
dc.creatorWANG, SHU H.
dc.creatorPARRA, DUCLERC F.
dc.creatorBUENO, RODRIGO F.
dc.creatorPEREYRA, INES
dc.creatorROSA, DERVAL S.
dc.date2023
dc.date2023-04-26T19:41:04Z
dc.date2023-04-26T19:41:04Z
dc.date.accessioned2023-09-28T14:25:52Z
dc.date.available2023-09-28T14:25:52Z
dc.identifier2373-9878
dc.identifierhttp://repositorio.ipen.br/handle/123456789/34016
dc.identifier4
dc.identifier9
dc.identifier10.1021/acsbiomaterials.2c01529
dc.identifier0000-0002-6481-0155
dc.identifier70
dc.identifier81.5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9004225
dc.descriptionBioinspired bactericidal surfaces are artificial surfaces that mimic the nanotopography of insect wings and are capable of inhibiting microbial growth by a physicomechanical mechanism. The scientific community has considered them an alternative method to design polymers with surfaces that inhibit bacterial biofilm formation, suitable for self-disinfectant medical devices. In this contribution, poly(lactic acid) (PLA) with nanocone patterns was successfully produced by a novel two-step procedure involving copper plasma deposition followed by argon plasma etching. According to reverse transcription-quantitative polymerase chain reaction tests, the bioinspired PLA nanostructures display antiviral performance to inactivate infectious Omicron severe acute respiratory syndrome coronavirus 2 particles, reducing the amount of the viral genome to less than 4% in just 15 min due to a possible combined effect of mechanical and oxidative stress. The bioinspired antiviral PLA can be suitable for designing personal protection equipment to prevent the transmission of contagious viral diseases, such as Coronavirus Disease 2019.
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionCoordena????o de Aperfei??oamento de Pessoal de N??vel Superior (CAPES)
dc.descriptionUniversidade Federal do ABC (UFABC)
dc.descriptionCNPq: 305819/2017-8; 402432/2020-7
dc.descriptionCAPES: 88881.504639/2020-01; 001
dc.descriptionUFABC: 48/2020-REIT (11.01)
dc.format1891-1899
dc.relationACS Biomaterials Science and Engineering
dc.rightsopenAccess
dc.subjectcoronaviruses
dc.subjecttopography
dc.subjectsurfaces
dc.subjectcopper
dc.subjectlactic acid
dc.subjectpolymers
dc.subjectantimicrobial agents
dc.titleBioinspired antimicrobial PLA with nanocones on the surface for rapid deactivation of Omicron SARS-CoV???2
dc.typeArtigo de peri??dico
dc.coverageI


Este ítem pertenece a la siguiente institución