Comparison of two light wavelengths (?? = 660 nm and ?? = 780 nm) in the repair process of oral mucositis induced by ionizing radiation

dc.creatorANDRADE, MAIRA F.
dc.creatorSARDO, ARIANE V.N.
dc.creatorBENETTI, CAROLINA
dc.creatorSICCHIERI, LETICIA B.
dc.creatorCORREA, LUCIANA
dc.creatorZEZELL, DENISE M.
dc.date2023
dc.date2023-04-25T15:44:13Z
dc.date2023-04-25T15:44:13Z
dc.date.accessioned2023-09-28T14:25:49Z
dc.date.available2023-09-28T14:25:49Z
dc.identifier2304-6732
dc.identifierhttp://repositorio.ipen.br/handle/123456789/34000
dc.identifier1
dc.identifier10
dc.identifier10.3390/photonics10010016
dc.identifier0000-0001-7404-9606
dc.identifier44.5
dc.identifier34
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9004209
dc.descriptionPhotobiomodulation (PBM) has been clinically used for the prevention and treatment of oral mucositis (OM). The effect of red and near-infrared wavelengths on OM repair is still misunderstood. The aim of this study was to compare the clinical effect and tissue changes caused by 660 nm and 780 nm exposure in an experimental model of OM. Rats were submitted to gamma irradiation for induction of OM lesions and treated with 660 nm or 780 nm lasers with the same dosimetry parameters (30 mW, 7.5 J/cm2, 10 s, spot size = 0.04 mm, irradiation every two days). Clinical assessment of OM severity and histopathological analyses was performed after 8, 14, and 20 days of the ionizing radiation. OM severity was reduced in the PBM groups, especially when the red laser was used. The histopathological pattern was similar between the PBM groups, showing advanced re-epithelization and more pronounced angiogenesis and collagen deposition compared to the control. The 660 nm group showed a greater collagen matrix area than the 780 nm group at 14 days. In conclusion, PBM at 660 nm and 780 nm improved the repair of ionizing radiation-induced OM. Both wavelengths activated the angiogenesis and collagen deposition, but these tissue effects were more pronounced when 660 nm was used.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionCoordena????o de Aperfei??oamento de Pessoal de N??vel Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionFAPESP: 17/50332-0; 13/26113-6; 17/07519-2
dc.descriptionCAPES: PROCAD 88881.068505/2014-01
dc.descriptionCNPq: INTC-465763/2014-6; PQ-314517/2021-9
dc.format1-13
dc.relationPhotonics
dc.rightsopenAccess
dc.subjectoral cavity
dc.subjectmucous membranes
dc.subjectinjuries
dc.subjectradiotherapy
dc.subjectlasers
dc.subjectionizing radiations
dc.titleComparison of two light wavelengths (?? = 660 nm and ?? = 780 nm) in the repair process of oral mucositis induced by ionizing radiation
dc.typeArtigo de peri??dico
dc.coverageI


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