Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings

dc.creatorGENESI, BIANCA P.
dc.creatorBARBOSA, RAQUEL de M.
dc.creatorSEVERINO, PATRICIA
dc.creatorRODAS, ANDREA C.D.
dc.creatorYOSHIDA, CRISTIANA M.P.
dc.creatorMATHOR, MONICA B.
dc.creatorLOPES, PATRICIA S.
dc.creatorVISERAS, CESAR
dc.creatorSOUTO, ELIANA B.
dc.creatorSILVA, CLASSIUS F. da
dc.date2023
dc.date2023-04-19T18:27:15Z
dc.date2023-04-19T18:27:15Z
dc.date.accessioned2023-09-28T14:25:46Z
dc.date.available2023-09-28T14:25:46Z
dc.identifier0378-5173
dc.identifierhttp://repositorio.ipen.br/handle/123456789/33984
dc.identifier634
dc.identifier10.1016/j.ijpharm.2023.122648
dc.identifier0000-0002-7294-9106
dc.identifier85.7
dc.identifier93
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9004193
dc.descriptionChitosan films are commonly used for wound dressing, provided that this polymer has healing, mucoadhesiveness and antimicrobial properties. These properties can be further reinforced by the combination of chitosan with polysaccharides and glycoproteins present in aloe vera, together with copaiba oleoresin???s pharmacological activity attributed to sesquiterpenes. In this work, we developed chitosan films containing either aloe vera, copaiba oil or both, by casting technique, and evaluated their microbial permeation, antimicrobial activity, cytotoxicity, and in vivo healing potential in female adult rats. None of the developed chitosan films promoted microbial permeation, while the cytotoxicity in Balb/c 3 T3 clone A31 cell line revealed no toxicity of films produced with 2 % of chitosan and up to 1 % of aloe vera and copaiba oleoresin. Films obtained with either 0.5 % chitosan or 0.5 % copaiba oleoresin induced cell proliferation which anticipate their potential for closure of wound and for the healing process. The in vivo results confirmed that tested films (0.5 % copaiba-loaded chitosan film and 0.5 % aloe vera-loaded chitosan film) were superior to a commercial dressing film. For all tested groups, a fully formed epithelium was seen, while neoformation of vessels seemed to be greater in formulations-treated groups than those treated with the control. Our work confirms the added value of combining chitosan with aloe vera and copaiba oil in the healing process of wounds.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionJunta de Andaluc??a
dc.descriptionFunda????o para a Ci??ncia e a Tecnologia (FCT)
dc.descriptionFAPESP: 10/17721-4
dc.descriptionJunta de Andaluc??a: PT18 RT 3786
dc.descriptionFCT: UIDP/04378/2020; UIDB/04378/2020; LA/P/0140/2020
dc.format1-12
dc.relationInternational Journal of Pharmaceutics
dc.rightsopenAccess
dc.subjectmedicinal plants
dc.subjecttrees
dc.subjectpolysaccharides
dc.subjectglycoproteins
dc.subjectwounds
dc.subjecthealing
dc.titleAloe vera and copaiba oleoresin-loaded chitosan films for wound dressings
dc.typeArtigo de peri??dico
dc.coverageI


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