Physicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(??-caprolactone)

dc.creatorKAIRALLA, ELENI C.
dc.creatorBRESSIANI, JOSE C.
dc.creatorBRESSIANI, ANA H. de A.
dc.creatorRIBELA, MARIA T. de C.P.
dc.creatorHIGA, OLGA Z.
dc.creatorQUEIROZ, ??LVARO A.A. de
dc.date2022
dc.date2023-01-23T18:22:48Z
dc.date2023-01-23T18:22:48Z
dc.date.accessioned2023-09-28T14:24:34Z
dc.date.available2023-09-28T14:24:34Z
dc.identifier0920-5063
dc.identifierhttp://repositorio.ipen.br/handle/123456789/33655
dc.identifier18
dc.identifier33
dc.identifier10.1080/09205063.2022.2104599
dc.identifier50.3
dc.identifier65.5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9003874
dc.descriptionTo overcome the disadvantages generated by the lack of interfacial bonding between hydroxyapatite nanocrystals (HAPN) and agglomeration of particles in the development of biodegradable nanocomposites a chemical grafting method was applied to modify the surface of HAPN through grafting of the three-arms star-shaped poly(??-caprolactone) (SPCL) onto the nanoparticles. The chemical grafting of SPCL onto HAPN (SPCL-g-HAPN) has been investigated using Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy (TEM), photoelectron spectroscopy, X-ray diffraction, zeta potential (ZP) and contact angle (CA). TEM micrographs of the SPCL-g-HAPN revealed the existence of hybrid organic/inorganic (O/I) nanoscale domains. The results of albumin (HSA) and fibrinogen (HFb) adsorption indicate resistance to HFb adsorption by SPCL-g-HAPN relatively to unmodified HAPN. The ZP and CA measurement suggest a heterogeneous topology for SPCL-g-HAPN likely due to the existence of hydrophobic-hydrophilic regions on the nanocomposite surface. The enzyme degradation by cholesterol esterase and lipase indicates that the rates of hydrolysis for SPCL-g-HAPN were very slow relative to the SPCL/HAPN blends. The in vitro biological studies showed that the human osteoblast-like cells (MG-63) cells had normal morphology and they were able to attach and spread out on SPCL-g-HAPN surfaces. A higher overall cellular proliferation was observed on SPCL-g-HAPN scaffolds compared to pure HAPN or SPCL materials.
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionCNPq: 307609/2018-9
dc.format2353-2384
dc.relationJournal of Biomaterials Science, Polymer Edition
dc.rightsopenAccess
dc.subjectORGANIC POLYMERS
dc.subjectNANOCRYSTALS
dc.subjectHYDROXY COMPOUNDS
dc.subjectBIODEGRADATION
dc.subjectNANOCOMPOSITES
dc.subjectAPATITES
dc.subjectPROTEIN
dc.subjectADSORPTION
dc.titlePhysicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(??-caprolactone)
dc.typeArtigo de peri??dico
dc.coverageI


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