Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine

dc.creatorARAUJO, GUILHERME R.S. de
dc.creatorMACIEIRA, GIVALDA M. da C.
dc.creatorOLIVEIRA, DAYANE X. de
dc.creatorMATOS, SAULO S.
dc.creatorSANTOS, QUESIA N. dos
dc.creatorOTUBO, LARISSA
dc.creatorARAUJO, ADRIANO A. de S.
dc.creatorDUARTE, MARCELO C.
dc.creatorLIRA, ANA A.M.
dc.creatorNUNES, ROGERIA de S.
dc.creatorSARMENTO, VICTOR H.V.
dc.date2022
dc.date2022-08-03T14:09:54Z
dc.date2022-08-03T14:09:54Z
dc.date.accessioned2023-09-28T14:22:45Z
dc.date.available2023-09-28T14:22:45Z
dc.identifier0927-7765
dc.identifierhttp://repositorio.ipen.br/handle/123456789/33167
dc.identifier214
dc.identifier10.1016/j.colsurfb.2022.112474
dc.identifier75.5
dc.identifier86.5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9003386
dc.descriptionNifedipine is a potent anti-hypertensive, which is poorly orally bioavailable on account of first-pass metabolism, short half-life, and low water solubility. This study aimed to develop a microemulsified system with low surfactant concentration and to evaluate the influence of microemulsion (ME) phase behavior on skin permeation of nifedipine, as drug model. Thereafter, MEs were obtained using PPG-5-CETETH-20, oleic acid, and phosphate buffer at pH 5.0. The selected MEs were isotropic, with droplet diameters less than 10 nm, polydispersity index < 0.25, and pH between 5.0 and 5.2. MEs presented low viscosity and Newtonian behavior. SAXS results confirmed bicontinuous and oil-in-water (o/w) MEs formation. The presence of the drug promoted only very slight modifications in the ME structure. The MEs presented ability to deliver nifedipine via the transdermal route when in comparison with the control. Nevertheless, the skin permeated and retained amounts from the o/w and bicontinuous formulations did not differ significantly. The ATR-FTIR demonstrated that both formulations promoted fluidization and disorganization of lipids and increased the drug diffusion and partition coefficients in the skin. In conclusion, PPG-5-CETETH-20 MEs obtained proved to be effective skin permeation enhancers, acting by rising the coefficients of partition and diffusion of the nifedipine in the skin.
dc.format1-9
dc.relationColloids and Surfaces B: Biointerfaces
dc.rightsopenAccess
dc.subjectemulsions
dc.subjectnanotechnology
dc.subjectsurfactants
dc.subjectdrug delivery
dc.titleMicroemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine
dc.typeArtigo de peri??dico
dc.coverageI


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