Light-based non-thermal therapy

dc.creatorRIBEIRO, MARTHA S.
dc.creatorCONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th
dc.date2022-03-25T15:27:06Z
dc.date2022-03-25T15:27:06Z
dc.dateOctober 4-8, 2021
dc.date.accessioned2023-09-28T14:21:36Z
dc.date.available2023-09-28T14:21:36Z
dc.identifierhttp://repositorio.ipen.br/handle/123456789/32860
dc.identifier0000-0002-4203-1134
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9003079
dc.descriptionLight-based non-thermal therapies are evolving as promising non-invasive and cost-effective medical technologies. These therapeutic platforms mainly encompass photobiomodulation (PBM) and photodynamic therapy (PDT), which use visible or near infrared (NIR) light to induce biological responses without any significant heating effects. For PBM, it is most commonly used red or NIR light to optimize light penetration into biological tissues. The photon absorption by natural chromophores at these spectral regions cause photophysical and photochemical reactions inside cells that trigger several biological effects such as to accelerate wound healing, reduce inflammation and relief pain, depending on light parameters and target tissue. On the other hand, PDT makes use of photoactivated drugs, also called as photosensitizers, which absorb light to induce chemical reactions that kill microbial or cancer cells by oxidative stress. Our group have been investigating the mechanisms and several applications of PBM and antimicrobial PDT (APDT) for almost 20 years. In this lecture I will share our experience in the area to discuss how PBM and APDT could be used to revolutionize health care in the photonics era. An integrated perspective from the basic mechanisms, preclinical and clinical trials for both therapies will be presented, including PBM on cancer management and APDT against drug-resistant pathogens. The lecture will also highlight future perspectives.
dc.format39-39
dc.publisherSociedade Brasileira de Bioqu??mica e Biologia Molecular (SBBq)
dc.rightsopenAccess
dc.subjectantimicrobial agents
dc.subjectphotodynamic therapy
dc.subjecttherapy
dc.subjectmodulation
dc.titleLight-based non-thermal therapy
dc.typeResumo de eventos cient??ficos
dc.coverageI
dc.localS??o Paulo, SP


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