dc.creator | RAMOS, C. | |
dc.creator | SOUZA, S. | |
dc.creator | TOBAR, N. | |
dc.creator | CASTRO, V. | |
dc.creator | FRASSON, F. | |
dc.creator | AMORIM, B. | |
dc.creator | ETCHEBEHERE, E. | |
dc.creator | LIMA, M. | |
dc.creator | MENGATTI, J. | |
dc.creator | ARAUJO, E. | |
dc.creator | PERINI, E. | |
dc.creator | SOUZA, C. | |
dc.creator | LORAND-METZE, I. | |
dc.creator | SANTOS, A. | |
dc.creator | DELAMAIN, M. | |
dc.date | 2020 | |
dc.date | 2022-02-04T17:04:19Z | |
dc.date | 2022-02-04T17:04:19Z | |
dc.date.accessioned | 2023-09-28T14:21:00Z | |
dc.date.available | 2023-09-28T14:21:00Z | |
dc.identifier | 1619-7070 | |
dc.identifier | http://repositorio.ipen.br/handle/123456789/32697 | |
dc.identifier | 47 | |
dc.identifier | Supplement 1 | |
dc.identifier | 10.1007/s00259-020-04988-4 | |
dc.identifier | 96.62 | |
dc.identifier | 98.00 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9002916 | |
dc.description | Aim/Introduction: Few reports have documented the uptake
of radiolabeled Prostate-Specific Membrane Antigen (PSMA)
in lymphomas [1,2]. It is not known how PSMA uptake
varies among various histological subtypes and how it
correlates with 18F-FDG uptake in lymphomas. This study
aimed to compare 68Ga-PSMA and 18F-FDG in different
lymphoma subtypes. Materials and Methods: Nine randomly
selected patients with biopsy-proven lymphoma -median
age 43 (32-70) years, 5 female - were submitted to whole-body
18F-FDG and 68Ga- PSMA PET/CT (time interval: 1-6
days between procedures). Lymphoma subtypes included:
nodular-sclerosis Hodgkin???s lymphoma (HL; 2 patients);
diffuse large B-cell lymphoma (DLBCL; 1); marginal-zone
lymphoma (2); MALT lymphoma (ML; 1); follicular lymphoma
(FL; 1); lymphoplasmacytic lymphoma (1); and B-cell non-
Hodgkin???s lymphoma, unspecified (BCNHL-U; 1). Eight
patients were under initial staging, and 1 (HL) with disease
relapse after treatment. Two experienced nuclear physicians
analyzed the images by consensus. The intensity of tracer
uptake was visually classified as marked, moderate or mild.
The affected sites (lymph node chains, spleen, diffuse bone
marrow involvement and non-lymphatic focal lesions)
were counted in both sets of images and their respective
maximum SUV (SUVmax) were measured. Results: PSMA PET/
CT was positive in all patients except for one with ML. FDG
PET/CT was positive in all patients. At visual analyses, FDG
uptake was higher than PSMA uptake in all patients, except
for one patient with BCNHL-U (both tracers with similar low-intensity
uptake). The intensity of FDG and PSMA uptake
was respectively classified as marked in 3/9 and 0/8 patients,
moderate in 4/9 and 1/8 and mild in 2/9 and 7/8. One patient
(FL) presented a ???mismatch??? uptake pattern with different parts of an extensive lesion presenting predominant uptake
of PSMA or FDG. Brain infiltration in one patient (DLBCL) was
more easily identified on PSMA than on FDG images. FDG
detected a total of 58/58 and PSMA 43/58 affected sites in all
patients with a median SUVmax of respectively 5.4 (2.0-31.1)
and 2.8 (1.3-5.4), p<0.0001. The median SUVs of the 43 lesions
with uptake of both tracers was respectively 5.5 (2.0-28.9)
and 2.8 (1.3-P5.4) for FDG and PSMA, p<0.0001. Conclusion:
Distinct lymphoma subtypes present PSMA uptake, with less
intensity than FDG uptake. Although PSMA uptake is usually
mild, several lymphoma subtypes might cause false-positive
results in PSMA PET/CT performed to assess prostate cancer. | |
dc.format | S41-S42 | |
dc.relation | European Journal of Nuclear Medicine and Molecular Imaging | |
dc.rights | openAccess | |
dc.source | Annual Congress of the European Association of Nuclear Medicine, 33rd, October 22-30, 2020, Online | |
dc.title | Comparison of 68Ga-PSMA and 18F-FDG PET/CT uptake in different lymphoma subtypes | |
dc.type | Resumos em peri??dicos | |
dc.coverage | I | |