New gold-198 nanoparticle synthesis to be used in cancer treatment

dc.creatorSOUZA, C.D. de
dc.creatorZEITUNI, C.A.
dc.creatorARCOS ROSERO, W.A.
dc.creatorNOGUEIRA, B.R.
dc.creatorROSTELATO, M.E.C.M.
dc.date2021
dc.date2021-08-02T16:49:05Z
dc.date2021-08-02T16:49:05Z
dc.date.accessioned2023-09-28T14:18:48Z
dc.date.available2023-09-28T14:18:48Z
dc.identifier2319-0612
dc.identifierhttp://repositorio.ipen.br/handle/123456789/32083
dc.identifier1A
dc.identifier9
dc.identifier10.15392/bjrs.v9i1A.1260
dc.identifier0000-0003-2943-6097
dc.identifier0000-0003-4609-2281
dc.identifier0000-0002-7303-6720
dc.identifierSem Percentil
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9002306
dc.descriptionGold nanoparticles (NPs) have been intriguing scientists for over 100 years. Recently, they have been studied for new applications such as cancer treatment. Although the synthesis of gold nanoparticles is extensively reported, in the majority of cases the methodology is confused and/or not clear. We describe a new synthesis methodology for radioactive gold???198 NPs. Gold-198 was activated in IPEN IEA-01 nuclear reactor. After that, chloroauric acid (HAuCl4) was formed by dissolving the radioactive gold with aqua regia and performing repeated heating cycles. 0.1 mM HAuCl4 containing 100 ??L of 1 M NaOH was prepared in a flask equipped with a reflux condenser. The solution was brought to boil and stirred with a PTFE???coated magnetic stir???bar. Then 5 mL of sodium citrate was rapidly added. The reaction turns from light yellow to clear, black, dark purple until the solution attained a wine???red color (2???3 min). Dynamic light scattering (DLS) confirmed 8 nm particles. The presence of gold???198 (197.968 g/mol; half???life: 2.69517; decay mode: ?????; average energy: 1.3723 MeV) was confirmed by an ORTEC HPGe detector. DLS was performed after complete decay confirming the 8 nm diameter maintenance. TEM analysis of the same solution yielded particles with 11 nm. We were able to achieve radioactive gold???198 NPs and are performing further studies such as: coating reactions, in???vitro and in???vivo studies.
dc.descriptionInternational Atomic Energy Agency (IAEA)
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionIAEA: BRA16021
dc.descriptionFAPESP: 18/18526-2
dc.format1-18
dc.relationBrazilian Journal of Radiation Sciences
dc.rightsopenAccess
dc.sourceMeeting on Nuclear Applications (ENAN), 14th, October 21-25, 2019, Santos, SP
dc.subjectatomic force microscopy
dc.subjectbrachytherapy
dc.subjectdecay
dc.subjectgold 198
dc.subjecthigh-purity ge detectors
dc.subjectlight scattering
dc.subjectnanoparticles
dc.subjectneoplasms
dc.subjectneutron flux
dc.subjectradiochemistry
dc.subjectsodium compounds
dc.subjectsynthesis
dc.subjectultraviolet radiation
dc.titleNew gold-198 nanoparticle synthesis to be used in cancer treatment
dc.typeArtigo de peri??dico
dc.coverageN


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