Influence of silicon, strontium and aluminum oxides on silicon nitride ceramics for bone replacements

dc.creatorNASCIMENTO, SERGIO F. do
dc.creatorRODAS, ANDREA C.D.
dc.creatorCARVALHO, FLAVIO M. de S.
dc.creatorHIGA, OLGA Z.
dc.creatorSILVA, CECILIA C.G. e
dc.date2020
dc.date2020-12-15T18:06:51Z
dc.date2020-12-15T18:06:51Z
dc.date.accessioned2023-09-28T14:17:15Z
dc.date.available2023-09-28T14:17:15Z
dc.identifier1517-7076
dc.identifierhttp://200.136.52.105/handle/123456789/31662
dc.identifier4
dc.identifier25
dc.identifier10.1590/S1517-707620200004.1178
dc.identifier1.35
dc.identifier12.67
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9001885
dc.descriptionAlthough silicon nitride ceramics have been shown very propitious to be used for bone replacements, some characteristics can be controlled to improve their osseointegrations process. One of them is the intergranular phase whose composition can be specified to stimulate mineralization and osteoblastic production. In this paper, the intergranular glassy phase was projected in order to contain silicon, strontium and aluminum oxides. Silicon nitride samples containing different contents of SiO2, SrO and Al2O3 were sintered at 1815oC for 1 hour and characterized by scanning electron microscopy and X-ray diffraction. Hardness and fracture toughness were determined by Vickers hardness test and compressive strength was evaluated using an universal material testing machine. The biological behavior was studied in regard to cytotoxicity and cell proliferation by means of in vitro experiments. The samples reached high densities (higher than 95 %TD), total ???????-Si3N4 transformation, fracture toughness higher than 6.5 MPa.m1/2, compressive strength up to 2500 MPa and Vickers hardness less than 9.8 GPa. All samples were non-cytotoxic and able to promote cell proliferation with great potential to be used as components for bone replacements. However, that sample with high content of strontium had the best results of cell proliferation, proving the importance of a careful choice of intergranular phase composition in silicon nitride ceramics.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionFAPESP: 15/02265-7
dc.relationRevista Mat??ria
dc.rightsopenAccess
dc.subjectsilicon nitrides
dc.subjectstrontium oxides
dc.subjectaluminium oxides
dc.subjectsilicon oxides
dc.subjectceramics
dc.subjectskeleton
dc.subjectconnective tissue cells
dc.subjectmechanical properties
dc.subjectmicrostructure
dc.subjecttoxicity
dc.subjectcell proliferation
dc.titleInfluence of silicon, strontium and aluminum oxides on silicon nitride ceramics for bone replacements
dc.typeArtigo de peri??dico
dc.coverageI


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