Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction

dc.creatorFREITAS, LUCAS F. de
dc.creatorCRUZ, CASSIA P.C. da
dc.creatorCAVALCANTE, ADRIANA K.
dc.creatorBATISTA, JORGE G. dos S.
dc.creatorVARCA, GUSTAVO H.C.
dc.creatorMATHOR, MONICA B.
dc.creatorLUGAO, ADEMAR B.
dc.date2020
dc.date2020-10-13T17:39:29Z
dc.date2020-10-13T17:39:29Z
dc.date.accessioned2023-09-28T14:16:18Z
dc.date.available2023-09-28T14:16:18Z
dc.identifier0969-806X
dc.identifierhttp://repositorio.ipen.br/handle/123456789/31427
dc.identifier174
dc.identifier10.1016/j.radphyschem.2020.108959
dc.identifier0000-0002-1737-3191
dc.identifier0000-0002-7294-9106
dc.identifier0000-0002-6545-237X
dc.identifier66.43
dc.identifier72.00
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9001650
dc.descriptionRadiolytic synthesis and phytochemical-driven gold reduction for the generation of nanoparticles are successful examples of Green Chemistry applied for nanomaterials. The present work compares these two green approaches focusing on hydrodynamic size, stability over time, optical properties and toxicity in NIH 3T3 (ATCC?? CRL- 1658???) cells and Danio rerio (Zebra Fish). The radiolytic synthesis was performed by mixing 1 mM NaAuCl4; polyvinyl pyrrolidone 0.5%, AgNO3 6??10???5 M, propan-2-ol 0.2 M and acetone 0.06 M, followed by irradiation at 15 kGy (5 kGy h???1, 60Co source). The EGCG-functionalized nanoparticles were synthesized by mixing 1.6 mM of Au with 0.8 mM of EGCG in phosphate buffer (10 mM) for 2 h. Both methods yield the formation of gold nanoparticles featuring plasmon resonance bands at 520???530 nm, polydispersity above 0.3 was relevant only for the radiolytic protocol. Regarding stability over time, after 30 days, the nanoparticles synthesized radiolytically presented no relevant size changes, while some aggregation was observed for the EGCG-particles. The same nanoparticles demonstrated a lack of stability in high ionic strength medium. Slight toxicity was observed for the EGCG-nanoparticles in Danio rerio, with an IC50 calculated as 40.49%, while no IC50 was established within the concentration range of radiolysis-AuNPs used in this study. In conclusion, both green methods generated nanoparticles with good control of size and optical properties, especially via reduction by EGCG. However, the stability and toxicity results were found to be more promising for the radiolytically synthesized gold nanoparticles.
dc.descriptionInternational Atomic Energy Agency (IAEA)
dc.descriptionConselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico (CNPq)
dc.descriptionIAEA: CRP F22064
dc.descriptionCNPq: 402887/2013-1
dc.format1-9
dc.relationRadiation Physics and Chemistry
dc.rightsopenAccess
dc.sourceInternational Meeting on Radiation Processing, 19th, April 01-05, 2019, Strasbourg, France
dc.subjectgold
dc.subjectnanoparticles
dc.subjectsynthesis
dc.subjectchemistry
dc.subjectecology
dc.subjectpolyphenols
dc.subjectfishes
dc.titleComparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction
dc.typeArtigo de peri??dico
dc.coverageI


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