Quantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography

dc.creatorALIBHAI, A.Y.
dc.creatorPRETTO, LUCAS R. de
dc.creatorMOULT, ERIC M.
dc.creatorOR, CHRIS
dc.creatorARYA, MALVIKA
dc.creatorMCGOWAN, MITCHELL
dc.creatorCARRASCO-ZEVALLOS, OSCAR
dc.creatorLEE, BYUNGKUN
dc.creatorCHEN, SIYU
dc.creatorBAUMAL, CAROLINE R.
dc.creatorWITKIN, ANDRE J.
dc.creatorREICHEL, ELIAS
dc.creatorFREITAS, ANDERSON Z. de
dc.creatorDUKER, JAY S.
dc.creatorFUJIMOTO, JAMES G.
dc.creatorWAHEED, NADIA K.
dc.date2020
dc.date2020-04-08T15:24:29Z
dc.date2020-04-08T15:24:29Z
dc.date.accessioned2023-09-28T14:15:11Z
dc.date.available2023-09-28T14:15:11Z
dc.identifier0275-004X
dc.identifierhttp://repositorio.ipen.br/handle/123456789/31114
dc.identifier3
dc.identifier40
dc.identifier10.1097/IAE.0000000000002403
dc.identifier0000-0002-5018-9126
dc.identifier84.68
dc.identifier92.00
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9001337
dc.descriptionPurpose: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm ?? 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0???0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2???3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0???14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionFAPESP: 16/17342-0; 15/15775-3
dc.format412-420
dc.relationRETINA, The Journal of Retinal and Vitreous Diseases
dc.rightsclosedAccess
dc.subjecttomography
dc.subjectcoherent radiation
dc.subjectoptical activity
dc.subjectoptical properties
dc.subjectcomputerized tomography
dc.subjectischemia
dc.subjectretina
dc.subjectdiabetes mellitus
dc.subjectpatients
dc.subjectperfused organs
dc.subjectcapillaries
dc.subjectstatistical data
dc.titleQuantification of retinal capillary nonperfusion in diabetics using wide-field optical coherence tomography angiography
dc.typeArtigo de peri??dico
dc.coverageI


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