[6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells

dc.creatorSILVA, J.P.L.
dc.creatorTEIXEIRA, L.F.
dc.creatorBELLINI, M.H.
dc.date2019
dc.date2020-02-21T12:15:24Z
dc.date2020-02-21T12:15:24Z
dc.date.accessioned2023-09-28T14:14:08Z
dc.date.available2023-09-28T14:14:08Z
dc.identifier2613-4942
dc.identifierhttp://repositorio.ipen.br/handle/123456789/30818
dc.identifier5
dc.identifier2
dc.identifier10.31487/j.COR.2019.05.07
dc.identifierSem Percentil
dc.identifierSem Percentil CiteScore
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9001045
dc.descriptionThe phenolic compound [6]-Gingerol, isolated from Zingiber officinale, has been demonstrated to have antitumor activity for different types of malignant tumours. Prostate cancer is the most common malignancy among males worldwide, being the second leading cause of cancer death in men. In the present study, we investigated the antitumor action of [6]-Gingerol on a human prostate cancer cell line (LNCaP). Our data shows that [6]-Gingerol treatment induced a dose-dependent decrease in the cell viability. Compared with the vehicle control, the cell viabilities were 79.90 ?? 3.56% and 53.06 ?? 7.82% when the LNCaP cells were exposed to 150 ??g/mL and 300 ??g/mL of [6]-Gingerol, respectively. The treatment of LNCaP with 300 ??M of [6]-Gingerol led to a significant reduction (~25%) on the clonogenic survival of these cells. Furthermore, [6]-gingerol acted as a radiosensitizer for LNCaP cells. The pretreatment of these cells with [6]-Gingerol significantly enhanced the killing effects of ionizing radiation with a dose enhancement ratio of 1.25. Our results demonstrate the anti-tumour activities of [6]-Gingerol. Further studies are needed to elucidate the mechanisms involved.
dc.descriptionFunda????o de Amparo ?? Pesquisa do Estado de S??o Paulo (FAPESP)
dc.descriptionFAPESP: 14/19265-7
dc.format1-3
dc.relationClinical Oncology and Research
dc.rightsopenAccess
dc.subjectprostate
dc.subjectneoplasms
dc.subjectradiosensitivity effects
dc.subjectradiosensitizers
dc.subjectradiosensitivity
dc.subjectclone cells
dc.subjectcloning
dc.subjectviability
dc.subjectmedicinal plants
dc.subjectspices
dc.subjectradiotherapy
dc.subjecttumor cells
dc.title[6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells
dc.typeArtigo de peri??dico
dc.coverageI


Este ítem pertenece a la siguiente institución