Decorated superparamagnetic iron oxide nanoparticles with monoclonal antibody and diethylene-triamine-pentaacetic acid labeled with thechnetium-99m and galium-68 for breast cancer imaging

dc.creatorALBERNAZ, MARTA de S.
dc.creatorTOMA, SERGIO H.
dc.creatorCLANTON, JEFF
dc.creatorARAKI, KOITI
dc.creatorSANTOS-OLIVEIRA, RALPH
dc.date2018
dc.date2018-07-11T12:34:52Z
dc.date2018-07-11T12:34:52Z
dc.date.accessioned2023-09-28T14:07:31Z
dc.date.available2023-09-28T14:07:31Z
dc.identifier0724-8741
dc.identifierhttp://repositorio.ipen.br/handle/123456789/28915
dc.identifier1
dc.identifier35
dc.identifier10.1007/s11095-017-2320-2
dc.identifier75.010
dc.identifier85.33
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8999160
dc.descriptionPurpose In this study we developed and tested an iron oxide nanoparticle conjugated with DTPA and Trastuzumab, which can efficiently be radiolabeled with 99m-Tc and Ga- 68, generating a nanoradiopharmaceutical agent to be used for SPECT and PET imaging. Methods The production of iron oxide nanoparticle conjugated with DTPA and Trastuzumab was made using phosphorylethanolamine (PEA) surface modification. Both radiolabeling process was made by the direct radiolabeling of the nanoparticles. The in vivo assay was done in female Balb/c nude mice xenografted with breast cancer. Also a planar imaging using the radiolabeled nanoparticle was performed. Results No thrombus and immune response leading to unwanted interaction and incorporation of nanoparticles by endothelium and organs, except filtration by the kidneys, was observed. In fact, more than 80% of 99mTc-DTPA-TZMB@Fe3O4 nanoparticles seems to be cleared by the renal pathway but the implanted tumor whose seems to increase the expression of HER2 receptors enhancing the uptake by all other organs.
dc.relationPharmaceutical Research
dc.rightsopenAccess
dc.subjectradiopharmaceuticals
dc.subjectnanoparticles
dc.subjectiron oxides
dc.subjecttechnetium 99
dc.subjectneoplasms
dc.subjectmammary glands
dc.subjectdiagnosis
dc.subjectdiagnostic uses
dc.subjectgallium 68
dc.subjectdtpa
dc.subjectmonoclonal antibodies
dc.subjectimages
dc.titleDecorated superparamagnetic iron oxide nanoparticles with monoclonal antibody and diethylene-triamine-pentaacetic acid labeled with thechnetium-99m and galium-68 for breast cancer imaging
dc.typeArtigo de peri??dico
dc.coverageI


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