Evaluation of resveratrol toxicity in the embryolarval stage of Danio rerio fish

dc.creatorCAVALCANTE, A.K.
dc.creatorLOPES-FERREIRA, M.
dc.creatorROGERO, S.O.
dc.creatorROGERO, J.R.
dc.date2017
dc.date2018-03-01T18:43:59Z
dc.date2018-03-01T18:43:59Z
dc.date.accessioned2023-09-28T14:06:31Z
dc.date.available2023-09-28T14:06:31Z
dc.identifier2317-9643
dc.identifierhttp://repositorio.ipen.br/handle/123456789/28616
dc.identifier01
dc.identifier12
dc.identifier10.5132/eec.2017.01.15
dc.identifier
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8998866
dc.descriptionHuman beings concern about healthy life has driven researchers to study new compounds capable of reaching that desire. Resveratrol (3, 4 ???, 5-trihydroxystilbene) a phenolic compound, is one of these substances which presents a variety of pharmacological actions, as antioxidant potential, anti-inflammatory capacity, protection against heart and cancer diseases. Despite the resveratrol health benefits studies, there is a little evidence of its toxicity in the literature in aquatic organisms, and especially the data on the concentration of resveratrol in the environment, making the present study fundamental for information about resveratrol ecotoxicity in the aquatic system. The aim of this study was to evaluate the toxicity of resveratrol in embryos and larvae of Danio rerio (zebrafish). The in vitro cytotoxicity and ecotoxicity assays were performed. The IC50 obtained in the NCTC-L929 cell line cytotoxicity assay was 38.5 mg L-1. The LC50 (96h) obtained in fish embryo toxicity test was 75.3 mg L-1 and the mean value of resveratrol LC50 (168h) obtained in the short-term chronic ecotoxicity assays performed with zebrafish larvae was 51.4 mg L-1. This work provided data on the toxicity of resveratrol in the embryonic stage of fish of the species Danio rerio and the toxic effects are dependent on its concentration.
dc.format133-139
dc.relationEcotoxicology and Environmental Contamination
dc.rightsopenAccess
dc.subjectfishes
dc.subjectembryos
dc.subjectquantitative chemical analysis
dc.subjectin vitro
dc.subjecthigh-performance liquid chromatography
dc.subjectecosystems
dc.subjecttoxicity
dc.subjectenzymes
dc.subjectdrugs
dc.subjectindustrial wastes
dc.subjectenvironmental impacts
dc.subjectpollution laws
dc.titleEvaluation of resveratrol toxicity in the embryolarval stage of Danio rerio fish
dc.typeArtigo de peri??dico
dc.coverageI


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