SPECT/CT with radiolabeled somatostatin analogues in the evaluation of systemic granulomatous infections

SPECT/CT com an??logos radiomarcados de somatostatina na avalia????o de infec????es granulomatosas sist??micas

dc.creatorMONTEIRO, PAULO H.S.
dc.creatorSOUZA, THIAGO F. de
dc.creatorMORETTI, MARIA L.
dc.creatorRESENDE, MARIANGELA R.
dc.creatorMENGATTI, JAIR
dc.creatorLIMA, MARIANA da C.L. de
dc.creatorSANTOS, ALLAN O.
dc.creatorRAMOS, CELSO D.
dc.date2017
dc.date2018-02-21T11:29:58Z
dc.date2018-02-21T11:29:58Z
dc.date.accessioned2023-09-28T14:06:12Z
dc.date.available2023-09-28T14:06:12Z
dc.identifier0100-3984
dc.identifierhttp://repositorio.ipen.br/handle/123456789/28520
dc.identifier6
dc.identifier50
dc.identifier10.1590/0100-3984.2016.0076
dc.identifier
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8998771
dc.descriptionObjective: To evaluate SPECT/CT with radiolabeled somatostatin analogues (RSAs) in systemic granulomatous infections in comparison with gallium-67 (67Ga) citrate scintigraphy. Materials and Methods: We studied 28 patients with active systemic granulomatous infections, including tuberculosis, paracoccidioidomycosis, pneumocystosis, cryptococcosis, aspergillosis, leishmaniasis, infectious vasculitis, and an unspecified opportunistic infection. Of the 28 patients, 23 had started specific treatment before the study outset. All patients underwent whole-body SPECT/CT imaging: 7 after injection of 99mTc-EDDA-HYNIC-TOC, and 21 after injection of 111In-DTPA-octreotide. All patients also underwent 67Ga citrate imaging, except for one patient who died before the 67Ga was available. Results: In 20 of the 27 patients who underwent imaging with both tracers, 27 sites of active disease were detected by 67Ga citrate imaging and by SPECT/CT with an RSA. Both tracers had negative results in the other 7 patients. RSA uptake was visually lower than 67Ga uptake in 11 of the 20 patients with positive images and similar to 67Ga uptake in the other 9 patients. The only patient who did not undergo 67Ga scintigraphy underwent 99mTc-EDDA-HYNIC-TOC SPECT/CT-guided biopsy of a lung cavity with focal RSA uptake, which turned to be positive for aspergillosis. Conclusion: SPECT/CT with 99mTc-EDDA-HYNIC-TOC or 111In-DTPA-octreotide seems to be a good alternative to 67Ga citrate imaging for the evaluation of patients with systemic granulomatous disease.
dc.format378-382
dc.relationRadiologia Brasileira
dc.rightsopenAccess
dc.subjectbiomedical radiography
dc.subjectcomputerized tomography
dc.subjectgallium 67
dc.subjectpatients
dc.subjectpositron computed tomography
dc.subjecttechnetium 99
dc.subjecttuberculosis
dc.titleSPECT/CT with radiolabeled somatostatin analogues in the evaluation of systemic granulomatous infections
dc.titleSPECT/CT com an??logos radiomarcados de somatostatina na avalia????o de infec????es granulomatosas sist??micas
dc.typeArtigo de peri??dico
dc.coverageI


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