Effect of gamma radiation on polyvinylpyrrolidone hydrogels

dc.creatorOLIVEIRA, M.J.A.
dc.creatorVASQUEZ, P.A.S.
dc.creatorALCANTARA, M.T.S.
dc.creatorMUNHOZ, M.M.L.
dc.creatorLUGAO, A.B.
dc.creatorINTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
dc.date2018-01-17T15:36:11Z
dc.date2018-01-17T15:36:11Z
dc.dateOctober 22-27, 2017
dc.date.accessioned2023-09-28T14:05:37Z
dc.date.available2023-09-28T14:05:37Z
dc.identifierhttp://repositorio.ipen.br/handle/123456789/28349
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8998603
dc.descriptionPolyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization, leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application. The results showed that mechanical strength was affected at doses starting at 25 kGy.
dc.publisherAssocia????o Brasileira de Energia Nuclear
dc.rightsopenAccess
dc.subjectabsorbed radiation doses
dc.subjectchemical properties
dc.subjectcobalt 60
dc.subjectdifferential thermal analysis
dc.subjectdose rates
dc.subjectfourier transformation
dc.subjectgamma radiation
dc.subjecthydrogels
dc.subjectinfrared spectra
dc.subjectphysical properties
dc.subjectpvp
dc.subjectradiation effects
dc.subjectswelling
dc.subjecttensile properties
dc.subjectthermal gravimetric analysis
dc.subjectwounds
dc.titleEffect of gamma radiation on polyvinylpyrrolidone hydrogels
dc.typeTexto completo de evento
dc.coverageI
dc.localRio de Janeiro, RJ


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