| dc.description | Purpose: There are several challenges when developing a laboratory to produce
radioactive sources. From choosing a prototype to radiation safety, the
task is enormous. During the past 15 years, our research group is developing
a laboratory to produce iodine-125 seed. These seeds are placed inside the
cancer and release radiation directly in the target. The whole production line
is full of new process and innovations. Among those, a new chemical reaction
that deposit iodine-125 onto silver (core) was developed. This paper presents
a comparison between vials in order to access their capability to retain
radioactive iodine. Also, the fixation percentage in a silver core was taken
into account. This information will be used to select a vial to be implemented
at the iodine-125 sources manufacture laboratory. Methods: Vials made
with polymers and glass was tested. Iodine-125 were placed in the vials overnight
at rt. Seven vials with different materials (glass, dark glass, and plastics)
were evaluated. Results: The selected vial (borosilicate glass 1 mL total volume)
loss 17.61% of iodine in 24 hours and presented the highest iodine
intake. It was noticeable that the vial material influenced both iodine intake
and iodine loss. The goal is to maximize the reaction yield to result in a less
costly product. Conclusion: We have selected the best vial for our reaction
in regards to leakage and yield. | |
