Anthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSakamoto, Claudio Alessandro M.
dc.creatorLopes, Welber Daniel Zanetti
dc.creatorBuzzulini, Carolina
dc.creatorCruz, Breno Cayeiro
dc.creatorFelippelli, Gustavo
dc.creatorde Lima, Roberto Cesar Araújo
dc.creatordos Santos, Thais Rabelo
dc.creatorSantana, Luis Fernando
dc.creatorde Mendonça, Rafael Paranhos
dc.creatorSoares, Vando Edésio
dc.creatorHenrique, Carlos Henrique
dc.creatorda Costa, Alvimar José
dc.date2014-05-27T11:30:51Z
dc.date2016-10-25T18:55:01Z
dc.date2014-05-27T11:30:51Z
dc.date2016-10-25T18:55:01Z
dc.date2013-10-16
dc.date.accessioned2017-04-06T02:41:58Z
dc.date.available2017-04-06T02:41:58Z
dc.identifierVeterinary Parasitology.
dc.identifier0304-4017
dc.identifier1873-2550
dc.identifierhttp://hdl.handle.net/11449/76863
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76863
dc.identifier10.1016/j.vetpar.2013.09.008
dc.identifierWOS:000330087400010
dc.identifier2-s2.0-84885348641
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2013.09.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897549
dc.descriptionAs a result of the need to develop new active principles for the control of endoparasites in ruminants, the present in vivo study evaluated a formulation containing 24% Aurixazol (48 mg/kg), a parasiticide molecule based on disophenolate of levamisole. Two experiments were conducted: one evaluating the anthelmintic efficacy of 24% Aurixazol (48 mg/kg) against gastrointestinal nematodes in naturally infected sheep, compared to an association of ivermectin (0.2 mg/kg) + albendazole (5.0 mg/kg) + levamisole (7.5 mg/kg) (IAL), and a second one which evaluated the persistent efficacy of the same formulation against immature stages (L4) and adults of Haemonchus contortus in experimentally infected animals. In experiment I, against H. contortus, the formulation of Aurixazol and the IAL association reached efficacies (arithmetic means) of 99.32% and 96.11%, respectively. For Trichostrongylus colubriformis, the efficacy values were 88.92% and 98.08% for Aurixazol and the IAL association, respectively. Both formulations were totally effective against Oesophagostomum columbianum (100%). The results of the statistical analysis demonstrated that the mean parasitic burden of treated animals was significantly different (P ≤ 0.05) compared to the average number of helminths diagnosed in animals from the control group for H. contortus, T. colubriformis and O. columbianum. Comparing only the treated groups, it was possible to verify that the average number of H. contortus recovered from animals treated with Aurixazol was different (P ≤ 0.05) when compared to the mean amount recovered from sheep treated with the IAL association. When evaluating the prevention of H. contortus infection in experiment II, Aurixazol did not present preventive efficacy. Up until 21 days after treatment the groups treated with Aurixazol contained less adults and L4 of H. contortus (P ≤ 0.05) when compared to the non-medicated control group. However, future studies will be necessary to assess the effectiveness of Aurixazol against nematode strains resistant to levamisole and disophenol, but the efficacy results described in this study allow to state that Aurixazol can, associated with other measures, become an important tool in the control of sheep nematodes. © 2013.
dc.languageeng
dc.relationVeterinary Parasitology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAurixazol
dc.subjectHelminths
dc.subjectPreventive efficacy
dc.subjectResistance
dc.subjectSheep
dc.titleAnthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep
dc.typeOtro


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