Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children

dc.creatorCastro, Ana Paula Pereira
dc.creatorHermsdorff, Helen Hermana Miranda
dc.creatorMilagres, Luana Cupertino
dc.creatorAlbuquerque, Fernanda Martins
dc.creatorFilgueiras, Mariana de Santis
dc.creatorRocha, Naruna Pereira
dc.creatorNovaes, Juliana Farias de
dc.date2018-04-19T14:57:36Z
dc.date2018-04-19T14:57:36Z
dc.date2018-02-10
dc.date.accessioned2023-09-27T22:23:45Z
dc.date.available2023-09-27T22:23:45Z
dc.identifier00217557
dc.identifierhttps://doi.org/10.1016/j.jped.2017.12.008
dc.identifierhttp://www.locus.ufv.br/handle/123456789/18859
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8974561
dc.descriptionTo investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa-MG. Anthropometric and body composition assessment, as well as biochemical profile of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire. Many children had excess weight (35.2%), abdominal adiposity (10.5%), and body fat (15.6%), as well as increased ApoB/ApoA1 ratio (14.7%), total cholesterol (51.8%), and triglycerides (19.8%). Children with excess weight and total and central fat had a higher prevalence of having a higher ApoB/ApoA1 ratio, as well as those with atherogenic lipid profile (increased LDL-c and triglycerides and low HDL-c). A direct association was found between the number of cardiovascular risk factors and the ApoB/ApoA1 ratio (p = 0.001), regardless of age and income. The increased ApoB/ApoA1 ratio was associated with excess weight, body adiposity (total and central), and altered lipid profile in children. Children with a higher number of cardiovascular risk factors had higher ApoB/ApoA1 ratio, in both genders.
dc.descriptionInvestigar a razão ApoB/ApoA1 e sua relação com fatores de risco cardiovascular em crianças. Trata-se de um estudo transversal com 258 crianças de 8 e 9 anos, matriculadas em todas escolas urbanas de Viçosa-MG. Foi realizada avaliação antropométrica, da composição corporal e bioquímica das crianças. As variáveis socioeconômicas e o sedentarismo foram avaliados por questionário semiestruturado. Muitas crianças apresentaram excesso de peso (35,2%), de adiposidade abdominal (10,5%) e de gordura corporal (15,6%), bem como a razão ApoB/ApoA1 (14,7%), colesterol-total (51,8%) e triglicerídeos (19,8%) aumentados. Crianças com excesso de peso e de gordura total e central apresentaram maiores prevalências de maior razão ApoB/ApoA1, bem como as com perfil lipídico aterogênico (LDL-c e triglicerídeos aumentados e baixo HDL-c). Foi encontrada associação direta entre o número de fatores de risco cardiovascular e a razão ApoB/ApoA1 (p = 0,001), independente da idade e renda. A razão ApoB/ApoA1 aumentada esteve associada ao excesso de peso, de adiposidade corporal (total e central) e ao perfil lipídico alterado nas crianças. As crianças com maior número de fatores de risco cardiovascular apresentaram maior razão ApoB/ApoA1, em ambos os sexos.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherJornal de Pediatria
dc.relationv. 629, p. 01-09, feb. 2018
dc.rightsOpen Access
dc.subjectChildren
dc.subjectLipids
dc.subjectAnthropometry
dc.subjectBody composition
dc.subjectApolipoproteins
dc.titleIncreased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children
dc.typeArtigo


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