Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMazoti, Marina Azer
dc.creatorBraz, Mariana Gobbo
dc.creatorGolim, Márjorie de Assis
dc.creatorBraz, Leandro Gobbo
dc.creatorDias, Norimar Hernandes
dc.creatorSalvadori, Daisy Maria Favero
dc.creatorBraz, José Reinaldo Cerqueira
dc.creatorFecchio, Denise
dc.date2014-05-27T11:30:46Z
dc.date2016-10-25T18:54:33Z
dc.date2014-05-27T11:30:46Z
dc.date2016-10-25T18:54:33Z
dc.date2013-10-01
dc.date.accessioned2017-04-06T02:40:14Z
dc.date.available2017-04-06T02:40:14Z
dc.identifierInflammation Research, v. 62, n. 10, p. 879-885, 2013.
dc.identifier1023-3830
dc.identifier1420-908X
dc.identifierhttp://hdl.handle.net/11449/76682
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76682
dc.identifier10.1007/s00011-013-0643-y
dc.identifierWOS:000324270100002
dc.identifier2-s2.0-84884676075
dc.identifier0000-0003-4413-226X
dc.identifierhttp://dx.doi.org/10.1007/s00011-013-0643-y
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897373
dc.descriptionObjective and design: The effects of anesthetics on cytokine release in patients without comorbidities who undergo minor surgery are not well defined. We compared inflammatory cytokine profiles in adult patients undergoing minimally invasive surgery who received isoflurane or propofol anesthesia. Methods: Thirty-four patients without comorbidities undergoing minor surgery were randomly assigned to receive an inhaled anesthetic (isoflurane; n = 16) or an intravenous anesthetic (propofol; n = 18). Blood samples were drawn before premedication and anesthesia (T1), 120 min after anesthesia induction (T2), and on the first post-operative day (T3). Plasma concentrations of interleukins (IL-) 1β, 6, 8, 10 and 12 and tumor necrosis factor (TNF)-α were measured using flow cytometry. Results: The pro-inflammatory cytokine IL-6 was increased in the isoflurane group at T2 and T3 compared to T1 (P < 0.01). In the propofol group, IL-6 and IL-8 were significantly increased at T3 compared to T1. However, there were no significant differences in cytokine concentrations between the isoflurane and propofol groups. Conclusion: An inflammatory response occurred earlier in patients who received an inhaled agent compared with an intravenous anesthetic, but no differences in plasma cytokine profiles were evident between isoflurane and propofol anesthesia in patients without comorbidities undergoing minimally invasive surgeries. © 2013 Springer Basel.
dc.languageeng
dc.relationInflammation Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytokines
dc.subjectFlow cytometry
dc.subjectInflammatory response
dc.subjectIsoflurane
dc.subjectMinor surgical procedures
dc.subjectPropofol
dc.titleComparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia
dc.typeOtro


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