Postprandial lipid response to high-saturated and high-monounsaturated fat meals in normal-weight or overweight women

dc.creatorLopes, Lılian L.
dc.creatorRocha, Daniela Mayumi U. P.
dc.creatorSilva, Alessandra da
dc.creatorPeluzio, Maria do Carmo G.
dc.creatorBressan, Josefina
dc.creatorHermsdorff, Helen Hermana M.
dc.date2018-04-19T19:48:42Z
dc.date2018-04-19T19:48:42Z
dc.date2018-02-09
dc.date.accessioned2023-09-27T22:13:52Z
dc.date.available2023-09-27T22:13:52Z
dc.identifier1541-1087
dc.identifierhttps://doi.org/10.1080/07315724.2017.1399835
dc.identifierhttp://www.locus.ufv.br/handle/123456789/18913
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8972444
dc.descriptionWe evaluated postprandial response of the lipid metabolism markers after the intake of a high-saturated fat (HSM) or high-monounsaturated fat meal (HMM). A randomized, controlled and acute intervention study included 63 women (age 26.9 ± 6.1 years): 35 normal weight (NW) and 28 overweight (OW) (total body fat [TBF] 24.7 ± 3.9% and 36.6 ± 3.9%, respectively). After 12 hours of fasting, each subject was given one of the two test meals standardized, including 2 muffins and water (HSM, 42.1% of saturated fat acid, or HMM, 34.5% of monounsaturated fat acid). Plasma fatty acid profile and concentrations of apolipoproteins A1 and B100, complement C3, and triacylglycerols were analyzed during fasting and at 2, 3, and 5 postprandial hours. Among the markers studied, the triacylglycerol (TAG) and complement C3 were significantly higher in the OW group, compared to NW. The increment in the C3 concentration was higher after HSM intake, compared with HMM (iAUC = 4365.5 ± 5477.4 vs. 1215.2 ± 882.4; p = 0.006), with no differences between groups. After 5 hours postprandial, plasma oleic acid values remained high compared with the fasting value in the NW group, but not in the OW group (26.0 ± 4.2 vs 23.7 ± 3.9%; p < 0.001). Women with high percentage of total plasma saturated fatty acids (SFA) at the beginning of the intervention had higher incremental area under the curve (iAUC) for the palmitic, stearic, and total fatty acids (p < 0.005). Those women with a high percentage of monounsaturated fatty acids (MUFA) showed lower iAUC values for the same fatty acid profile (p < 0.005). This study demonstrated the effect of the HSM on postprandial increment of C3 concentration, suggesting another mechanism for saturated fat metabolism. The postprandial response to HSM appears to be the mediated by baseline lipid profile of the individuals, while the response to HMM was correlated to the weight status.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherJournal of the American College of Nutrition
dc.relationVolume 37. Issue 1, 2018
dc.rightsAmerican College of Nutrition
dc.subjectLipid metabolism
dc.subjectComplement C3
dc.subjectPostprandial period
dc.subjectObesity
dc.subjectMonounsaturated fatty acids and saturated fatty acids
dc.titlePostprandial lipid response to high-saturated and high-monounsaturated fat meals in normal-weight or overweight women
dc.typeArtigo


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