Glucose homoeostasis in rats exposed to acute intermittent hypoxia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRafacho, A.
dc.creatorGonçalves-Neto, L. M.
dc.creatorFerreira, F. B D
dc.creatorProtzek, A. O P
dc.creatorBoschero, A. C.
dc.creatorNunes, E. A.
dc.creatorZoccal, Daniel Breseghello
dc.date2014-05-27T11:30:33Z
dc.date2016-10-25T18:53:34Z
dc.date2014-05-27T11:30:33Z
dc.date2016-10-25T18:53:34Z
dc.date2013-09-01
dc.date.accessioned2017-04-06T02:37:11Z
dc.date.available2017-04-06T02:37:11Z
dc.identifierActa Physiologica, v. 209, n. 1, p. 77-89, 2013.
dc.identifier1748-1708
dc.identifier1748-1716
dc.identifierhttp://hdl.handle.net/11449/76438
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76438
dc.identifier10.1111/apha.12118
dc.identifier2-s2.0-84881545277
dc.identifierhttp://dx.doi.org/10.1111/apha.12118
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/897137
dc.descriptionAim: Chronic exposure to intermittent hypoxia commonly induces the activation of sympathetic tonus and the disruption of glucose homoeostasis. However, the effects of exposure to acute intermittent hypoxia (AIH) on glucose homoeostasis are not yet fully elucidated. Herein, we evaluated parameters related to glucose metabolism in rats exposed to AIH. Methods: Male adult rats were submitted to 10 episodes of hypoxia (6% O2, for 45 s) interspersed with 5-min intervals of normoxia (21%), while the control (CTL) group was kept in normoxia. Results: Acute intermittent hypoxia rats presented higher fasting glycaemia, normal insulinaemia, increased lactataemia and similar serum lipid levels, compared to controls (n = 10, P < 0.05). Additionally, AIH rats exhibited increased glucose tolerance (GT) (n = 10, P < 0.05) and augmented insulin sensitivity (IS) (n = 10, P < 0.05). The p-Akt/Akt protein ratio was increased in the muscle, but not in the liver and adipose tissue of AIH rats (n = 6, P < 0.05). The elevated glycaemia in AIH rats was associated with a reduction in the hepatic glycogen content (n = 10, P < 0.05). Moreover, the AIH-induced increase in blood glucose concentration, as well as reduced hepatic glycogen content, was prevented by prior systemic administration of the β-adrenergic antagonist (P < 0.05). The effects of AIH on glycaemia and Akt phosphorylation were transient and not observed after 60 min. Conclusions: We suggest that AIH induces an increase in blood glucose concentration as a result of hepatic glycogenolysis recruitment through sympathetic activation. The augmentation of GT and IS might be attributed, at least in part, to increased β-adrenergic sympathetic stimulation and Akt protein activation in skeletal muscles, leading to a higher glucose availability and utilization. © 2013 Scandinavian Physiological Society.
dc.languageeng
dc.relationActa Physiologica
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood glucose
dc.subjectGlucose tolerance
dc.subjectInsulin sensitivity
dc.subjectIntermittent hypoxia
dc.subjectPropranolol
dc.subjectSympathetic activity
dc.subjectglucose
dc.subjectglycogen
dc.subjectinsulin
dc.subjectlactic acid
dc.subjectlipid
dc.subjectpropranolol
dc.subjectprotein kinase B
dc.subjectadipose tissue
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectgluconeogenesis
dc.subjectglucose blood level
dc.subjectglucose homeostasis
dc.subjectglucose metabolism
dc.subjectglucose tolerance
dc.subjectglycogen liver level
dc.subjectheart rate
dc.subjecthyperlipidemia
dc.subjectinsulin blood level
dc.subjectinsulin sensitivity
dc.subjectinsulinemia
dc.subjectintermittent hypoxia
dc.subjectlactate blood level
dc.subjectlipid blood level
dc.subjectliver
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmetabolic parameters
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein phosphorylation
dc.subjectrat
dc.subjectskeletal muscle
dc.subjectsympathetic function
dc.titleGlucose homoeostasis in rats exposed to acute intermittent hypoxia
dc.typeOtro


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