Digested total protein and protein fractions from chia seed (Salvia hispanica L.) had high scavenging capacity and inhibited 5-LOX, COX-1-2, and iNOS enzymes

dc.creatorGrancieri, Mariana
dc.creatorMartino, Hercia Stampini Duarte
dc.creatorMejia, Elvira Gonzalez de
dc.date2019-04-10T17:48:38Z
dc.date2019-04-10T17:48:38Z
dc.date2019-08-15
dc.date.accessioned2023-09-27T22:02:50Z
dc.date.available2023-09-27T22:02:50Z
dc.identifier0308-8146
dc.identifierhttps://doi.org/10.1016/j.foodchem.2019.03.036
dc.identifierhttp://www.locus.ufv.br/handle/123456789/24451
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8969931
dc.descriptionThe objective was to identify and characterize peptides from digested total protein (DTP) and isolated protein fractions (DPF), and their potential antioxidant, anti-inflammatory and anti-atherosclerotic effects, from chia seed (Salvia hispanica L.). Total protein and protein fractions from chia seed underwent simulated gastrointestinal digestion. The sequence, physicochemical properties, and biological potential of peptides were determined using chemical, in silico, and biochemical assays. Peptides from DTP (n = 9) and DPF albumin (n = 12), globulin (n = 11), prolamin (n = 5) and glutelin (n = 17) had interaction with cyclooxygenase-2 (COX-2), p65- nuclear factor kappa B, lipoxygenase-1 (LOX-1) and toll-like receptor 4 (p < 0.05). DTP, and digested albumin, globulin, and glutelin showed scavenging capacity for superoxide, hydrogen peroxide, nitric oxide and DPPH (1,1-diphenyl-2-picrylhydrazyl), and inhibition of 5-LOX, COX-1-2, and inducible nitric oxide synthase (iNOS) enzymes (p < 0.05). Chia seed proteins has peptides with potential beneficial health effects highlighting the importance of chia consumption.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFood Chemistry
dc.relationVolume 289, Pages 204-214, August 2019
dc.rightsElsevier B. V.
dc.subjectChia seeds
dc.subjectPeptides
dc.subjectSimulated gastrointestinal digestion
dc.subjectInflammation
dc.subjectAntioxidant
dc.subjectAtherosclerosis
dc.titleDigested total protein and protein fractions from chia seed (Salvia hispanica L.) had high scavenging capacity and inhibited 5-LOX, COX-1-2, and iNOS enzymes
dc.typeArtigo


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