The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling

dc.creatorRocha, Carolina S.
dc.creatorSantos, Anésia A.
dc.creatorMachado, João Paulo B.
dc.creatorFontes, Elizabeth P.B.
dc.date2017-11-28T10:39:12Z
dc.date2017-11-28T10:39:12Z
dc.date2008-08-02
dc.date.accessioned2023-09-27T22:00:38Z
dc.date.available2023-09-27T22:00:38Z
dc.identifier00426822
dc.identifierhttps://doi.org/10.1016/j.virol.2008.08.005
dc.identifierhttp://www.locus.ufv.br/handle/123456789/13866
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8969406
dc.descriptionThe NIK (NSP-interacting kinase)-mediated antiviral signaling pathway was identified as a virulence target of the begomovirus nuclear shuttle protein (NSP). Here, we further characterized this layer of plant innate defense by identifying the ribosomal protein L10 (rpL10), a QM-like protein, as a downstream effector of the antiviral signaling. Although both ribosomal proteins rpL10 and rpL18 were found to associate with NIK1 through yeast two-hybrid screening, the NIK receptors specifically phosphorylated rpL10 in vitro. Furthermore, loss of rpL10 function significantly increased susceptibility to begomovirus infection, recapitulating the phenotype of nik knockout lines. Our results genetically linked rpL10 to the NIK-mediated antiviral signaling.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherVirology
dc.relationVolume 380, Issue 2, Pages 165-169, October 2008
dc.rightsOpen Access
dc.subjectBegomovirus
dc.subjectAntiviral signaling
dc.subjectNIK receptor
dc.subjectRibosomal protein L10
dc.subjectReceptor-like kinase
dc.titleThe ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling
dc.typeArtigo


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