Novel zinc(ii) derivatives of phenol schiff bases: synthesis, characterisation, crystal structure and antimicrobial activity

dc.creatorSantos, A. F. da S.
dc.creatorSouza, M. C. de
dc.creatorDiniz, R.
dc.creatorMaia, J. R. da S.
dc.date2019-01-22T11:57:27Z
dc.date2019-01-22T11:57:27Z
dc.date2018
dc.date.accessioned2023-09-27T21:56:03Z
dc.date.available2023-09-27T21:56:03Z
dc.identifier2527-1075
dc.identifierhttps://doi.org/10.18540/jcecvl4iss1pp0019-0027
dc.identifierhttp://www.locus.ufv.br/handle/123456789/23129
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8968291
dc.descriptionZinc(II)-Schiff base derivatives of general formula [Zn(L)Cl] n.xH2O {n = 2; x = 1, L = 3- hmp (1), L = 4-hmp (2); x = 0, L = hmyp (3)} were synthesized by the condensation reaction of aminophenol with 2-hydroxybenzaldehyde. The Schiff bases in complex-1, 2 and 3 are bonded to the metal through the nitrogen and oxygen atoms. These complexes have dimeric structures with bridging oxygen atom. The metal is at the centre of a tetrahedron (1 and 2), and at a square pyramidal geometry (3), according to the X-ray diffraction analyses. They were characterized by IR, NMR (1H, 13C), molar conductivity, melting point and microanalyses. The bioassay of these Zn(II) derivatives on strains of S. aureus, B. subtillis, E. coli and S. typhimurium showed MICs between 60 and 520 μM. Complex-2 showed the best antibacterial result with MIC of 65 μM against the Gram-positive bacteria.
dc.descriptionCompostos de zinco(II) com bases de Schiff de fórmula geral [Zn(L)Cl] n.xH2O {n = 2; x = 1, L = 3-hmp (1), L = 4-hmp (2); x = 0, L = hmyp (3)} foram preparados mediante reação de condensação entre aminofenol com 2-hidroxibenzaldeído. As bases de Schiff nos complexos 1, 2 e 3 formam ligações ao centro metálico via os átomos de nitrogênio e oxigênio. Estes compostos têm uma estrutura dimérica com átomos de oxigênio em ponte. O metal se encontra no centro de um tetraedro (1 e 2) e de uma pirâmide de base quadrada (3), segundo análise por difração de raios-X. Os compostos foram caracterizados por IR, RMN (1H e 13C), condutividade molar, pontos de fusão e microanálise. Ensaios biológicos em cepas de S. aureus, B. subtillis, E. coli e S. typhimurium mostraram MICs entre 60 e 520 μM. O complexo 2 mostrou o melhor resultado bactericida com MIC de 65 μM contra as bactérias Gram positivas.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherThe Journal of Engineering and Exact Sciences
dc.relationv. 4, n. 1, p. 19- 27, 2018
dc.rightsOpen Access
dc.subjectBases de Schiff
dc.subjectComplexos de zinco(II)
dc.subjectEstrutura cristalina
dc.subjectAtividade antibacteriana
dc.subjectSchiff bases
dc.subjectZinc(II) complexes
dc.subjectCrystal structure
dc.subjectAntibacterial activity
dc.titleNovel zinc(ii) derivatives of phenol schiff bases: synthesis, characterisation, crystal structure and antimicrobial activity
dc.typeArtigo


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