Bovine mature adipocytes readily return to a proliferative state

dc.creatorDuarte, M. S.
dc.creatorWei, S.
dc.creatorDu, M.
dc.creatorPaulino, P. V. R.
dc.creatorJiang, Z.
dc.creatorAlbrecht, E.
dc.creatorFernyhough-Culver, M.
dc.creatorZan, L.
dc.creatorHausman, G. J.
dc.creatorDodson, M. V.
dc.date2018-09-28T12:31:58Z
dc.date2018-09-28T12:31:58Z
dc.date2012-12
dc.date.accessioned2023-09-27T21:53:22Z
dc.date.available2023-09-27T21:53:22Z
dc.identifier00408166
dc.identifierhttps://doi.org/10.1016/j.tice.2012.08.001
dc.identifierhttp://www.locus.ufv.br/handle/123456789/22067
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8967651
dc.descriptionThe dynamics of human and animal adipogenesis has been defined using several traditional cell systems including stromal vascular cells and adipocyte-related cell lines. But a relatively new cell system using progeny cells stemming from the dedifferentiation of purified cultures of mature adipocytes may be used for studying the development and biology of adipocytes. In this research, we show that isolated (and purified) mature adipocytes derived from Wagyu cattle dedifferentiate into progeny cells, and that these spindle-shaped, proliferative-competent daughter cells possess ability to proliferate. We outline the optimum cell culture system and offer precautionary thoughts for effective mature adipocyte culture. Collectively, this represents a novel cell model which may provide new insights into cell development, physiology and use as a model for animal production/composition, tissue engineering and disease treatment.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherTissue and Cell
dc.relationv. 44, n. 6, p. 385- 390, dez. 2012
dc.rightsElsevier Ltd.
dc.subjectMature adipocytes
dc.subjectProliferation
dc.subjectDFAT cells
dc.titleBovine mature adipocytes readily return to a proliferative state
dc.typeArtigo


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