Persistent inflammation in the CNS during chronic EAE despite local absence of IL-17 production

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorZorzella-Pezavento, Sofia Fernanda Gonçalves
dc.creatorChiuso-Minicucci, Fernanda
dc.creatorFrança, Thais Graziela Donegá
dc.creatorIshikawa, Larissa Lumi Watanabe
dc.creatorDa Rosa, Larissa Camargo
dc.creatorMarques, Camila
dc.creatorIkoma, Maura Rosane Valerio
dc.creatorSartori, Alexandrina
dc.date2014-05-27T11:29:58Z
dc.date2016-10-25T18:51:17Z
dc.date2014-05-27T11:29:58Z
dc.date2016-10-25T18:51:17Z
dc.date2013-07-19
dc.date.accessioned2017-04-06T02:31:24Z
dc.date.available2017-04-06T02:31:24Z
dc.identifierMediators of Inflammation, v. 2013.
dc.identifier0962-9351
dc.identifier1466-1861
dc.identifierhttp://hdl.handle.net/11449/76011
dc.identifierhttp://acervodigital.unesp.br/handle/11449/76011
dc.identifier10.1155/2013/519627
dc.identifierWOS:000321660200001
dc.identifier2-s2.0-84880150391.pdf
dc.identifier2-s2.0-84880150391
dc.identifierhttp://dx.doi.org/10.1155/2013/519627
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896726
dc.descriptionExperimental autoimmune encephalomyelitis (EAE) is an artificially induced demyelination of the central nervous system (CNS) that resembles multiple sclerosis in its clinical, histopathological, and immunological features. Activated Th1 and Th17 cells are thought to be the main immunological players during EAE development. This study was designed to evaluate peripheral and local contribution of IL-17 to acute and chronic EAE stages. C57BL/6 mice were immunized with MOG plus complete Freund's adjuvant followed by pertussis toxin. Mice presented an initial acute phase characterized by accentuated weight loss and high clinical score, followed by a partial recovery when the animals reached normal body weight and smaller clinical scores. Spleen cells stimulated with MOG produced significantly higher levels of IFN-γ during the acute period whereas similar IL-17 levels were produced during both disease stages. CNS-infiltrating cells stimulated with MOG produced similar amounts of IFN-γ but, IL-17 was produced only at the acute phase of EAE. The percentage of Foxp3+ Treg cells, at the spleen and CNS, was elevated during both phases. The degree of inflammation was similar at both disease stages. Partial clinical recovery observed during chronic EAE was associated with no IL-17 production and presence of Foxp3+ Treg cells in the CNS. © 2013 Sofia Fernanda Gonçalves Zorzella-Pezavento et al.
dc.languageeng
dc.relationMediators of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFreund adjuvant
dc.subjectgamma interferon
dc.subjectinterleukin 17
dc.subjectmyelin oligodendrocyte glycoprotein
dc.subjectpertussis toxin
dc.subjecttranscription factor FOXP3
dc.subjectallergic encephalomyelitis
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbody weight
dc.subjectcell infiltration
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdisease severity
dc.subjectfemale
dc.subjectinflammatory infiltrate
dc.subjectmouse
dc.subjectnervous system inflammation
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectregulatory T lymphocyte
dc.subjectscoring system
dc.subjectspleen cell
dc.subjectweight reduction
dc.titlePersistent inflammation in the CNS during chronic EAE despite local absence of IL-17 production
dc.typeOtro


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