New rubrolide analogues as inhibitors of photosynthesis light reactions

dc.creatorVarejão, Jodieh O.S.
dc.creatorBarbosa, Luiz C.A.
dc.creatorRamos, Gabriela Álvarez
dc.creatorVarejão, Eduardo V.V.
dc.creatorKing-Díaz, Beatriz
dc.creatorLotina-Hennsen, Blas
dc.date2018-05-25T15:42:20Z
dc.date2018-05-25T15:42:20Z
dc.date2015-03-01
dc.date.accessioned2023-09-27T21:48:39Z
dc.date.available2023-09-27T21:48:39Z
dc.identifier10111344
dc.identifierhttps://doi.org/10.1016/j.jphotobiol.2015.02.016
dc.identifierhttp://www.locus.ufv.br/handle/123456789/19813
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8966487
dc.descriptionNatural products called rubrolides have been investigated as a model for the development of new herbi- cides that act on the photosynthesis apparatus. This study comprises a comprehensive analysis of the photosynthesis inhibitory ability of 27 new structurally diverse rubrolide analogues. In general, the results revealed that the compounds exhibited efficient inhibition of the photosynthetic process, but in some cases low water solubility may be a limiting factor. To elucidate their mode of action, the effects of the compounds on PSII and PSI, as well as their partial reaction on chloroplasts and the chlorophyll a fluorescence transients were measured. Our results showed that some of the most active rubrolide ana- logues act as a Hill reaction inhibitors at the QB level by interacting with the D1 protein at the reducing side of PSII. All of the active analogues follow Tice’s rule of 5, which indicates that these compounds pre- sent physicochemical properties suitable for herbicides.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherJournal of Photochemistry and Photobiology B:
dc.relationv. 145, p. 11-18, Abril 2015
dc.rightsElsevier B.V.
dc.subjectRubrolide
dc.subjectPhotosynthesis light
dc.titleNew rubrolide analogues as inhibitors of photosynthesis light reactions
dc.typeArtigo


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