Larvicidal activity of synthetic tropane alkaloids against Ascia monuste orseis (Lepidoptera: Pieridae)

dc.creatorMairink, Simone Z
dc.creatorBarbosa, Luiz CA
dc.creatorVarejão, Eduardo VV
dc.creatorFarias, Elizeu S
dc.creatorSantos, Márcio LM
dc.creatorPicanço, Marcelo C
dc.date2018-04-23T12:11:23Z
dc.date2018-04-23T12:11:23Z
dc.date2017-03-06
dc.date.accessioned2023-09-27T21:46:01Z
dc.date.available2023-09-27T21:46:01Z
dc.identifier1526-4998
dc.identifierhttps://doi.org/10.1002/ps.4565
dc.identifierhttp://www.locus.ufv.br/handle/123456789/19032
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8965834
dc.descriptionTropane alkaloids are known to play a role in plant defence. By blocking acetylcholine receptors, they exert insecticidal and deterrent effects against herbivore insects. Carbamates are an important class of chemical insecticides that also inhibit acetyl cholinesterase. The objective of this work was to synthesise a series of tropane alkaloids bearing a carbamate group, and to evaluate their effects against the pest Ascia monuste. The effects of the most active compounds were evaluated on the A. monuste predatorSolenopsis saevissima and on the pollinator Tetragonisca angustula. The synthesis of carbamate‐tropane alkaloids was accomplished in 4–5 steps from commercially available ketones. Results from bioassays showed that compounds 6a, 10a and 14a presented higher activities against second‐instar larvae of A. monuste, with LD50values of 1.01, 3.76 and 1.92 µg substance mg−1 insect, and TL50 values of 7.0, 15.0 and 5.0 h respectively. These compounds were also tested for their selectivity in favour of S. saevissima and T. angustula. Compound 6a, which showed the highest activity against A. monuste, also showed lower toxicity against S. saevissima. Tropane alkaloid derivatives bearing a carbamate group show potential for the development of novel insecticides against A. monuste. © 2017 Society of Chemical Industry
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherPest Management Science
dc.relationv. 73, issue 10, p. 2048–2053, oct. 2017
dc.rightsOpen Access
dc.subjectInsecticide activity
dc.subjectTropane alkaloids
dc.subjectCarbamate
dc.subjectAscia monuste
dc.subjectSolenopsis saevissima
dc.subjectTetragonisca angustula
dc.titleLarvicidal activity of synthetic tropane alkaloids against Ascia monuste orseis (Lepidoptera: Pieridae)
dc.typeArtigo


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