dc.creatorLima, Luciana Moreira
dc.creatorCarvalho, Maria das Graças
dc.creatorSousa, Marinez de Oliveira
dc.date2017-10-23T16:03:02Z
dc.date2017-10-23T16:03:02Z
dc.date2012-08-06
dc.date.accessioned2023-09-27T21:45:08Z
dc.date.available2023-09-27T21:45:08Z
dc.identifier1806-0870
dc.identifierhttp://dx.doi.org/10.5581/1516-8484.20120075
dc.identifierhttp://www.locus.ufv.br/handle/123456789/12279
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8965601
dc.descriptionThe formation of thrombi at the site of atherosclerotic lesions plays a central role in atherothrombosis. Impaired fibrinolysis may exacerbate pre-existing coronary artery disease and potentiate its evolution. While the fibrinogen plasma level has been strongly associated with the severity of coronary artery disease, its relevance in the evaluation of plasminogen in coronary artery disease patients remains unclear. This study evaluated fibrinogen and plasminogen levels in subjects with coronary artery disease as diagnosed by angiography. This is a cross-sectional study. Blood samples obtained from 17 subjects with angiographically normal coronary arteries (controls), 12 with mild/moderate atheromatosis and 28 with severe atheromatosis were evaluated. Plasma plasminogen and fibrinogen levels were measured by chromogenic and coagulometric methods, respectively. Fibrinogen levels were significantly higher in the severe atheromatosis group compared to the other groups(p-value < 0.0001). A significant positive correlation was observed between the severity of coronary artery diseaseand increasing fibrinogen levels (r = 0.50; p-value < 0.0001) and between fibrinogen and plasminogen levels (r =0.46; p-value < 0.0001). There were no significant differences in the plasminogen levels between groups. Plasma fibrinogen, but not plasminogen levels were higher in patients with coronary artery disease compared to angiographically normal subjects. The plasma fibrinogen levels also appear to be associated with the severity of the disease. The results of this study provide no evidence of a significant correlation between plasma plasminogen levels and the progress of coronary stenosis in the study population.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherRevista Brasileira de Hematologia e Hemoterapia
dc.relation34(4) p.298-301, August 2012
dc.rightsOpen Access
dc.subjectPlasminogen
dc.subjectFibrinogen
dc.subjectFibrinogenCoronary artery disease
dc.titlePlasminogen and fibrinogen plasma levels in coronary artery disease
dc.typeArtigo


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