Marjolin's ulcer in two horses with hereditary equine regional dermal asthenia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBadial, Peres R.
dc.creatorRashmir-Raven, Ann M.
dc.creatorCagnini, Didier Q.
dc.creatorOliveira-Filho, José P.
dc.creatorCooley, Avery J.
dc.creatorCunha, Paulo Henrique J.
dc.creatorKitchell, Barbara E.
dc.creatorConceição, Lissandro G.
dc.creatorMochal, Cathleen A.
dc.creatorBorges, Alexandre Secorun
dc.date2014-05-27T11:29:49Z
dc.date2016-10-25T18:50:19Z
dc.date2014-05-27T11:29:49Z
dc.date2016-10-25T18:50:19Z
dc.date2013-07-01
dc.date.accessioned2017-04-06T02:28:38Z
dc.date.available2017-04-06T02:28:38Z
dc.identifierJournal of Equine Veterinary Science, v. 33, n. 7, p. 515-522, 2013.
dc.identifier0737-0806
dc.identifierhttp://hdl.handle.net/11449/75767
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75767
dc.identifier10.1016/j.jevs.2012.03.004
dc.identifierWOS:000321794000006
dc.identifier2-s2.0-84879779708.pdf
dc.identifier2-s2.0-84879779708
dc.identifierhttp://dx.doi.org/10.1016/j.jevs.2012.03.004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896500
dc.descriptionTwo Quarter Horse mares with hereditary equine regional dermal asthenia (HERDA) were diagnosed with metastatic squamous cell carcinoma (SCC) associated with chronic nonhealing wounds. The lesions were similar to the development of SCC from chronic nonhealing ulcers, known as Marjolin's ulcers in humans. The horses showed recurrent skin wounds in the saddle and paralumbar regions and were confirmed by molecular techniques as having HERDA. Both horses were maintained as research animals for prolonged periods and received regular veterinary care and wound treatment. Both horses were ultimately euthanized because of their chronic progressive wounds, coupled with declining health. At necropsy, the nonhealing wounds were found to be complicated by infiltrative SCC; both horses had metastasis to lungs. Chronically inflamed, recurrent skin wounds that heal slowly and incompletely as a consequence of HERDA are proposed as a major pathogenetic factor in tumorigenesis. Consistent findings with respect to proliferation index (Ki-67) and mutations of p53 tumor suppressor gene were confirmed by immunohistochemistry in one horse. SCC consistent with Marjolin's ulcer has been previously suggested in association with chronic ulcers or burn scars in horses, but this is the first report of an association with chronic poor healing wounds in HERDA horses. © 2013 Elsevier Inc.
dc.languageeng
dc.relationJournal of Equine Veterinary Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHERDA
dc.subjectHorse
dc.subjectMarjolin's ulcer
dc.subjectSquamous cell carcinoma
dc.subjectAnimalia
dc.subjectEquidae
dc.titleMarjolin's ulcer in two horses with hereditary equine regional dermal asthenia
dc.typeOtro


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