Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats

dc.creatorMoreira, Maria Eliza de Castro
dc.creatorAraújo, Fernanda de Oliveira
dc.creatorSousa, Andressa Rodrigues de
dc.creatorToledo, Renata Celi Lopes
dc.creatorBenjamin, Laércio dos Anjos
dc.creatorSantos, Marcelo Henrique dos
dc.creatorMartino, Hercia Stampini Duarte
dc.creatorVeloso, Marcia Paranho
dc.creatorReis, Kassius de Souza
dc.date2019-02-21T11:29:56Z
dc.date2019-02-21T11:29:56Z
dc.date2018-12
dc.date.accessioned2023-09-27T21:42:14Z
dc.date.available2023-09-27T21:42:14Z
dc.identifier0963-9969
dc.identifierhttps://doi.org/10.1016/j.foodres.2018.08.004
dc.identifierhttp://www.locus.ufv.br/handle/123456789/23631
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8964891
dc.descriptionThe aim was to evaluate the effect of the ethanol extract of bacupari peel (EEB) on biometric measurements, hepatic lipogenesis and progression of non-alcoholic fatty liver disease (NAFLD) in obese Wistar rats. Chemical analysis of the bacupari peel extract identified 7-epiclusianone as the major constituent (140.02 mg/g) followed by morelloflavone (35.86 mg/g). Animals treated with high fat diet plus EEB (BHFD) reduced body mass index (BMI), liver weight and hepatosomatic index in relation to the obese control. The food intake was similar between hyperlipid group (HFD) groups with or without EEB. However, the normal control group (AIN-93 M) presented higher food intake and lower final weight compared to the obese control (HFD). The PPAR-α, CPT-1a and the ADIPOR2 genes expressions, and the concentration of the PPAR-α and the adiponectin protein level increased in the BHFD group in relation to the obese control. The EEB promoted reduction of the SREBP-1c gene expression and the percentage of hepatic fat and the degree of steatosis in relation to HFD. It was concluded that EEB showed a protective effect on NAFLD, as it promoted a reduction in BMI, induced lipid oxidation, reduced lipogenesis and hepatic steatosis. Moreover, our results suggest an interaction that can lead to an agonist activity of the EEB to the PPAR-α receptor.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFood Research International
dc.relationVolume 114, Pages 169- 177, December 2018
dc.rights2018 Elsevier Ltd. All rights reserved.
dc.subjectAdiponectin
dc.subjectADIPOR2
dc.subjectNonalcoholic fatty liver disease
dc.subjectPPAR-ɑ
dc.subjectRheedia brasiliensis
dc.titleBacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats
dc.typeArtigo


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