Histopathology of the tegument of rabbits infested by Rhipicephalus sanguineus (ACARI: IXODIDAE) ticks and exposed to selamectin (active principle of acaricide Revolution®, Pfizer)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBozzatto, Vlamir
dc.creatorDe Oliveira, Patrícia Rosa
dc.creatorCamargo-Mathias, Maria Izabel
dc.date2014-05-27T11:29:48Z
dc.date2016-10-25T18:50:14Z
dc.date2014-05-27T11:29:48Z
dc.date2016-10-25T18:50:14Z
dc.date2013-07-01
dc.date.accessioned2017-04-06T02:28:20Z
dc.date.available2017-04-06T02:28:20Z
dc.identifierParasitology Research, v. 112, n. 7, p. 2551-2560, 2013.
dc.identifier0932-0113
dc.identifier1432-1955
dc.identifierhttp://hdl.handle.net/11449/75738
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75738
dc.identifier10.1007/s00436-013-3422-3
dc.identifierWOS:000320516500016
dc.identifier2-s2.0-84879549956
dc.identifierhttp://dx.doi.org/10.1007/s00436-013-3422-3
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896472
dc.descriptionTicks are hematophagous ectoparasites which can transmit several diseases to the host during their feeding process. When ticks mechanically damage the tissue, they eventually induce inflammatory responses on the skin spot where they are fixed. One of the alternatives to control these ectoparasites is the use of chemical substances like selamectin - the active principle of Pfizer's antiparasitic Revolution® - a macrocyclic lactone capable of doing neurotoxic damage to the tick and eventually eliminating infestation in dogs and cats. The purpose of this study was to analyze, using histological and histochemical techniques, the occurrence of morphophysiological alterations in the skin of the host rabbits exposed to selamectin and infested with Rhipicephalus sanguineus (Acari: Ixodidae). Histologically, the exposed and infested rabbits showed a partial and/or total decrease in the stratum corneum and the epithelium decreased in the number of cell layers, consequently reducing the stratification (thinning) and quite pronounced formations of sub-epidermal edemas with consequent disorganization of collagen fibers in the dermal layer's connective tissue. Histochemical tests showed strong periodic acid-Schiff-positive reaction in the hair follicle and some regions of the dermis, besides resynthesis of collagen fibers detected by Mallory's trichrome technique. The obtained results showed that selamectin acts like a toxicant agent when in contact with the skin of the rabbit infested with ticks, inducing morphophysiological alterations in the acute inflammatory process in the animal's tegument. Selamectin is a chemical substance which has a dose-dependent action since higher concentrations cause greater morphophysiological damage in the skin of rabbits. © 2013 Springer-Verlag Berlin Heidelberg.
dc.languageeng
dc.relationParasitology Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcollagen fiber
dc.subjectrevolution
dc.subjectselamectin
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcollagen synthesis
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug exposure
dc.subjecthair follicle
dc.subjecthistochemistry
dc.subjecthistopathology
dc.subjectintegument
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectRhipicephalus sanguineus
dc.subjectskin defect
dc.subjectskin edema
dc.subjectskin epithelium
dc.subjectskin toxicity
dc.subjectstratum corneum
dc.subjecttick infestation
dc.subjectAcari
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.subjectIxodida
dc.subjectIxodidae
dc.subjectOryctolagus cuniculus
dc.titleHistopathology of the tegument of rabbits infested by Rhipicephalus sanguineus (ACARI: IXODIDAE) ticks and exposed to selamectin (active principle of acaricide Revolution®, Pfizer)
dc.typeOtro


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