Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorUtsunomiya, Yuri T.
dc.creatordo Carmo, Adriana S.
dc.creatorCarvalheiro, Roberto
dc.creatorNeves, Haroldo H.R.
dc.creatorMatos, Márcia C.
dc.creatorZavarez, Ludmilla B.
dc.creatorPérez O'Brien, Ana M.
dc.creatorSölkner, Johann
dc.creatorMcEwan, John C.
dc.creatorCole, John B.
dc.creatorVan Tassell, Curtis P.
dc.creatorSchenkel, Flávio S.
dc.creatorda Silva, Marcos V.G.B.
dc.creatorPorto Neto, Laercio R.
dc.creatorSonstegard, Tad S.
dc.creatorGarcia, José Fernando
dc.date2014-05-27T11:29:40Z
dc.date2016-10-25T18:49:46Z
dc.date2014-05-27T11:29:40Z
dc.date2016-10-25T18:49:46Z
dc.date2013-06-13
dc.date.accessioned2017-04-06T02:26:43Z
dc.date.available2017-04-06T02:26:43Z
dc.identifierBMC Genetics, v. 14.
dc.identifier1471-2156
dc.identifierhttp://hdl.handle.net/11449/75650
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75650
dc.identifier10.1186/1471-2156-14-52
dc.identifierWOS:000320374900001
dc.identifier2-s2.0-84878817065.pdf
dc.identifier2-s2.0-84878817065
dc.identifierhttp://dx.doi.org/10.1186/1471-2156-14-52
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896388
dc.descriptionBackground: Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs).Results: The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length.Conclusions: This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus). © 2013 Utsunomiya et al.; licensee BioMed Central Ltd.
dc.languageeng
dc.relationBMC Genetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBirth weight
dc.subjectBos primigenius indicus
dc.subjectGWAS
dc.subjectNellore cattle
dc.subjectStature
dc.subjectCHCHD7 protein
dc.subjectMOS protein
dc.subjectPENK protein
dc.subjectPLAG1 protein
dc.subjectprotein kinase Lyn
dc.subjectprotein tyrosine kinase
dc.subjectRDHE2 protein
dc.subjectRPS20 protein
dc.subjectSDR16C5 protein
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectautosome
dc.subjectbirth weight
dc.subjectbody height
dc.subjectBos taurus
dc.subjectbreeding
dc.subjectcarcass
dc.subjectcattle
dc.subjectchromosome NOR
dc.subjectcontrolled study
dc.subjectgene expression
dc.subjectgene location
dc.subjectgene mapping
dc.subjectgenetic association
dc.subjectgenetic linkage
dc.subjectgenotype
dc.subjectgestational age
dc.subjectnonhuman
dc.subjectorthology
dc.subjectprogeny
dc.subjectquantitative trait locus
dc.subjectsingle nucleotide polymorphism
dc.subjectswine
dc.subjectweaning
dc.subjectweight gain
dc.subjectBos
dc.subjectBos indicus
dc.subjectBovinae
dc.subjectSuidae
dc.titleGenome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height
dc.typeOtro


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