Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system

dc.creatorRocha, Júlio Cézar Barbosa
dc.creatorOliveira, Michele F.
dc.creatorSuarez, Diego
dc.creatorTeixeira, Alvaro Vianna Novaes de Carvalho
dc.creatorCortés, Maria E.
dc.creatorSousa, Frederico B. De
dc.creatorSinisterra, Rubén D.
dc.date2018-05-04T15:23:19Z
dc.date2018-05-04T15:23:19Z
dc.date2015-09-01
dc.date.accessioned2023-09-27T21:26:46Z
dc.date.available2023-09-27T21:26:46Z
dc.identifier09284931
dc.identifierhttps://doi.org/10.1016/j.msec.2015.04.042
dc.identifierhttp://www.locus.ufv.br/handle/123456789/19337
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8960739
dc.descriptionHerein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP). For this purpose, polyCD was synthesized and characterized, and its biocompatibility was assessed using fibroblast cytotoxicity tests. Moreover, the interactions between the guest PROP molecule and both polyCD and βCD were found to be spontaneous. Subsequently, PROP was encapsulated in uniaxial and coaxial polyCD/ PMAA nanofibers. A lower PROP burst effect (reduction of approximately 50%) and higher modulation were observed from the coaxial than from the uniaxial fibers. Thus, the coaxial nanofibers could potentially be a useful strategy for developing a controlled release system for hydrophilic molecules.
dc.formatpdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherMaterials Science and Engineering: C
dc.relationv. 54, p. 252-261, sep. 2015
dc.rightsElsevier B.V.
dc.subjectElectrospinning
dc.subjectPolymeric nanofibers
dc.subjectPoly-cyclodextrin
dc.subjectDrug delivery system
dc.subjectPropranolol
dc.titleElectrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system
dc.typeArtigo


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